Malformations of cortical development

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dc.authorscopusid7003442366
dc.authorscopusid6602372330
dc.authorscopusid7005934743
dc.contributor.authorGüngör S.
dc.contributor.authorYalnizo?lu D.
dc.contributor.authorTopçu M.
dc.date.accessioned2024-08-04T19:59:05Z
dc.date.available2024-08-04T19:59:05Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPatients with malformations of cortical development (MCD) present with a wide spectrum of clinical manifestations ranging from asymptomatic cases to those with epilepsy and developmental problems. Clinical presentation of MCD is variable and depends on the affected cortical area. While severe malformations can be recognized with definite developmental retardation and early-onset recurrent seizures, mild malformations are usually identified at any age, mostly during evaluation following a seizure. With the help of high resolution neuroradiological imaging techniques, there has been an increase in the number of cortical developmental lesions. The etiology in many MCDs is unknown. It is possibly a general response of the developing brain to genetic and environmental factors. Alterations during neuronal proliferation, migration and organization stages of the developing brain constitute the basis of these malformations. During the developmental stages, intervening genetic and prenatal environmental factors may contribute to the development of malformations. Nevertheless, in the majority of cases the cause is unknown.en_US
dc.identifier.endpage225en_US
dc.identifier.issn0010-0161
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-35348968930en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://hdl.handle.net/11616/90376
dc.identifier.volume50en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofCocuk Sagligi ve Hastaliklari Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClinical courseen_US
dc.subjectEtiologyen_US
dc.subjectGeneticen_US
dc.subjectMalformations of cortical developmenten_US
dc.titleMalformations of cortical developmenten_US
dc.title.alternativeKortikal gelişimsel malformasyonlaren_US
dc.typeReview Articleen_US

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