In vitro antimicrobial and antioxidant activity of acetone and methanol extracts from Thymus leucotrichius (Lamiaceae)

dc.authoridCigremis, Yilmaz/0000-0002-8600-0946;
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.contributor.authorUlukanli, Z.
dc.contributor.authorCigremis, Y.
dc.contributor.authorIlcim, A.
dc.date.accessioned2024-08-04T20:32:54Z
dc.date.available2024-08-04T20:32:54Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Objectives: Thymus species has been used as tonic and herbal tea, antiseptic, antitussive, carminative, antioxidant, anti-inflammatory and antimicrobial activities. The acetone and methanol extracts of Thymus (T.) leucotrichius (Labiatae/Lamiaceae) was examined for antimicrobial and antioxidant properties. Materials and Methods: The antioxidant properties of acetone and methanol extracts of Thymus leucotrichius were investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH)/nitric oxide (NO) radical scavenging activity, reducing power and total phenolic substance analysis. Antibacterial, antiyeast and antifungal activity of the plant extracts were tested using the disc diffusion method. Results and Discussion: Results showed that IC50 of Thymus leucotrichius acetone and methanol extracts that scavenged 50% of the DPPH radical in the medium was found to be 109.72 mu g/ml, 43.53 mu g/ml, respectively. It was found that IC50 of Thymus leucotrichius acetone and methanol extracts which scavenged 50% of the NO radical in the medium was 180.56 mu g/ml, and 67.34 mu g/ml, respectively. In the Thymus leucotrichius acetone and methanol extracts (1 mg), 35.64 mu g and 51.78 mu g pyrocatechol equivalents of phenols were detected, respectively. Neither acetone nor methanol extract possessed activity towards Proteus vulgaris, Rhodotorula rubra, Candida albicans, Aspergillus parasiticus and Aspergillus niger. Acetone extract was the most active on Bacillus cereus and Bacillus megaterium. The sentivity was also observed against towards Escherichia coli H7:O157, Kluvyeromyces fragilis and Fusarium proliferatum when acetone extract used. The methanol extract also displayed more or less similar inhibitory activity towards the test microorganisms. Kluvyeromyces fragilis was resistant to methanol extract of the species unlike acetone extracts of the species. However, the fungus Fusarium proliferatum was markedly inhibited by the methanol extract of test species at 1000 mu g and above. Significant inhibitory activities of the two extracts were based upon the increasing dose-dependent level.en_US
dc.identifier.endpage657en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid21796869en_US
dc.identifier.scopus2-s2.0-79960353119en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage649en_US
dc.identifier.urihttps://hdl.handle.net/11616/95380
dc.identifier.volume15en_US
dc.identifier.wosWOS:000292470900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymus leucotrichiusen_US
dc.subjectAntibacterialen_US
dc.subjectAntiyeasten_US
dc.subjectAntifungalen_US
dc.subjectAntioxidant activityen_US
dc.titleIn vitro antimicrobial and antioxidant activity of acetone and methanol extracts from Thymus leucotrichius (Lamiaceae)en_US
dc.typeArticleen_US

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