The effects of intracerebroventricular infusion of irisin on feeding behaviour in rats

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidErden, Yavuz/AAJ-7783-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.contributor.authorTekin, Suat
dc.contributor.authorErden, Yavuz
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorColak, Cemil
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:43:00Z
dc.date.available2024-08-04T20:43:00Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIrisin, a novel exercise-induced myokine, has attracted attention with its effects on energy metabolism. This study was conducted to determine the possible effects of irisin on nutritional behaviour. In this study, 40 male Wistar Albino rats were separated into 4 groups (n =10 for each group). Osmotic mini-pumps were connected to metal cannulas implanted to lateral ventricle; and artificial cerebrospinal fluid (vehicle), and 10 and 100 nM of irisin was infused for 7 days. The daily food and water consumptions and body weights of rats were followed up. After the infusion, the animals were killed, and the hypothalamus and blood samples were collected. NPY, POMC, and UCP2 mRNA levels in the hypothalamus were examined by RT-PCR. In serum, leptin and ghrelin levels as well as the levels of metabolic parameters were measured by using ELISA. It was determined that irisin administration increased the daily food consumption (p < 0.05), without causing significant changes in water consumption and body weight. Irisin also caused increases in ghrelin level in circulation and NPY and UCP2 mRNA levels in the hypothalamus, whereas it decreased the leptin level in circulation and POMC mRNA levels in the hypothalamus (p < 0.05). Otherwise, irisin caused decrease in LDL, triglycerides and cholesterol levels, while increasing HDL and glucose levels (p < 0.05). Results indicates that long-term irisin treatment increases food intake without increasing body weight associated with increased ghrelin, NPY and UCP2 mRNAs, and decreased leptin and POMC mRNA in the hypothalamus. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [114S138]en_US
dc.description.sponsorshipThis study was supported by The Scientific & Technological Research Council of Turkey (TUBITAK; Project no:114S138).en_US
dc.identifier.doi10.1016/j.neulet.2017.02.066
dc.identifier.endpage32en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid28242329en_US
dc.identifier.scopus2-s2.0-85014339952en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2017.02.066
dc.identifier.urihttps://hdl.handle.net/11616/97715
dc.identifier.volume645en_US
dc.identifier.wosWOS:000401679400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody weighten_US
dc.subjectFood intakeen_US
dc.subjectIrisinen_US
dc.subjectNPYen_US
dc.subjectPOMCen_US
dc.subjectUCP2en_US
dc.titleThe effects of intracerebroventricular infusion of irisin on feeding behaviour in ratsen_US
dc.typeArticleen_US

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