Is obesity genetic disease?
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Obesity is a complex disease that has unfavorable impacts for all ethnic populations in worldwide. Genetics, environment and lifestyle
are among aetiological factors of this disease. Genetic contribution associated with this disease is generally classified into 2 types:
monogenic syndromes that display severe obesity, and the polygenic model of common obesity. Single-gene mutations can cause
severe obesity resulting from alteration in central and peripheral appetite control mechanisms. Candidate gene and genome-wide
association studies have led to the identification of nine loci associated with Mendelian forms of obesity and 58 loci contributing
to polygenic obesity. These loci explain a small fraction of the heritability for obesity and many genes remain to be identified. The
interaction of several polymorphisms and epigenetic modifications open a new research field for common obesity. As a result, still
remains to be a mystery
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
WoS Q DeÄŸeri
Scopus Q DeÄŸeri
Cilt
Sayı
Künye
Duran, T., Akram Zainalbden, H., & Kocak, N. (2021). Is obesity genetic disease? . Annals of Medical Research, 24(4), 0531–0534. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/1568
