Evaluation of salivary total oxidant-antioxidant status and DNA damage of children undergoing fixed orthodontic therapy

dc.authoridGuler, Cigdem/0000-0002-2581-9050
dc.authoridOtlu, Onder/0000-0001-5958-7609
dc.authorwosidGuler, Cigdem/KPA-0490-2024
dc.authorwosidOtlu, Onder/W-3887-2018
dc.contributor.authorGuler, Cigdem
dc.contributor.authorToy, Ebubekir
dc.contributor.authorOzturk, Firat
dc.contributor.authorGunes, Dilek
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorOtlu, Onder
dc.date.accessioned2024-08-04T20:40:07Z
dc.date.available2024-08-04T20:40:07Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy. Materials and Methods: Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo. The salivary levels of TOS, TAS, and 8-OHdG were determined three times, as follows: before treatment (T-1) and at 1 month (T-2) and 3 months (T-3) following appliance placement. All data were statistically analyzed. Results: There were no significant differences in TOS, TAS, and 8-OHdG within the same time periods among the three different orthodontic composites (P > .05). TAS in all composite groups decreased over time. These decreases were found to be significant for Kurasper F and GrenGloo at the T1 T3 and T2 T3 time periods (P < .05). In all composite groups 8-OHdG decreased between T1 and T2 (P < .05). However, 8-OHdG in all composite groups increased from T2 to T3. These differences in 8-OHdG were significant in Kurasper F and GrenGloo (P < .05). Conclusions: Fixed orthodontic appliances bonded with the tested composites did not increase the cytotoxicity markers in saliva.en_US
dc.identifier.doi10.2319/110113-798.1
dc.identifier.endpage244en_US
dc.identifier.issn0003-3219
dc.identifier.issn1945-7103
dc.identifier.issue2en_US
dc.identifier.pmid24949910en_US
dc.identifier.scopus2-s2.0-84924865802en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.2319/110113-798.1
dc.identifier.urihttps://hdl.handle.net/11616/96709
dc.identifier.volume85en_US
dc.identifier.wosWOS:000350531200010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE H Angle Education Research Foundation, Incen_US
dc.relation.ispartofAngle Orthodontisten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTotal oxidant statusen_US
dc.subjectTotal antioxidant statusen_US
dc.subject8-Hydroxy-2 '-deoxyguanosineen_US
dc.titleEvaluation of salivary total oxidant-antioxidant status and DNA damage of children undergoing fixed orthodontic therapyen_US
dc.typeArticleen_US

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