Effects of extended cold exposure on antioxidant defense system of rat hypothalamic-pituitary-adrenal axis

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dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authoridAsma, Dilek/0000-0002-3866-3016
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.authorwosidAsma, Dilek/AAA-5294-2021
dc.contributor.authorYüksel, S
dc.contributor.authorAsma, D
dc.date.accessioned2024-08-04T20:15:22Z
dc.date.available2024-08-04T20:15:22Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of our study was to investigate the effect of extended (48 h) cold (8 degrees C) exposure on oxidative stress and antioxidant defense system in hypothalamus and adrenal medulla, which are both key components of the hypothalamic-pituitary-adrenal (HPA) axis. Male albino Spraque-Dawley rats were randomly divided into two groups-the control group (n = 12) and the cold stress group (n = 12). Tissue superoxide dismutase (SOD), catalase (CAT), glutathion S-transferase (GST) and glutathion reductase (GR) activities and glutathion (GSH) were measured using chemical protocols. In cold stress groups CAT activities were significantly increased in adrenal medulla and hypothalamus of rats; however, SOD activities were decreased in both tissues. Sub-acute cold exposure resulted in a significant increase in GR activity while GST was decrease in both tissues studied. The amount of GSH was also enhanced in adrenal medulla and hypothalamus of cold-stressed rats when compared to controls. Extended exposure of cold caused synergic changes in the hypothalamic and adrenal medullary antioxidative enzyme activities. This results lead us to conclude that cold stress can disrupt the balance in an oxidant/antioxidant system and cause oxidative damage to HPA axis organs by altering the enzymatic and non-enzymatic antioxidant status. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jtherbio.2005.12.007
dc.identifier.endpage317en_US
dc.identifier.issn0306-4565
dc.identifier.issn1879-0992
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-33645417572en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtherbio.2005.12.007
dc.identifier.urihttps://hdl.handle.net/11616/94338
dc.identifier.volume31en_US
dc.identifier.wosWOS:000237171000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal of Thermal Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcold stressen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant enzymesen_US
dc.subjectHPAen_US
dc.subjectraten_US
dc.titleEffects of extended cold exposure on antioxidant defense system of rat hypothalamic-pituitary-adrenal axisen_US
dc.typeArticleen_US

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