Adrenomedullin and total nitrite levels in children with familial Mediterranean fever

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridtekin, deniz/0000-0001-9654-3664
dc.authoridBalat, Ayse/0000-0002-8904-1348
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidtekin, deniz/AAM-8858-2020
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.contributor.authorBalat, A
dc.contributor.authorIslek, I
dc.contributor.authorÇekmen, M
dc.contributor.authorYürekli, M
dc.contributor.authorTekin, D
dc.contributor.authorMuslu, A
dc.contributor.authorSahinöz, S
dc.date.accessioned2024-08-04T20:15:25Z
dc.date.available2024-08-04T20:15:25Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Familial Mediterranean fever (FMF) is the most frequent periodic syndrome characterised by recurrent attacks of polyserositis. However, recent studies revealed that there might be an ongoing subclinical inflammation between the attacks. As nitric oxide (NO) and adrenomedullin (AM) are both synthesised in the endothelium, and mediates many functions within immune system, we considered them to be an interesting target of investigation in FMF. Methods: Fifteen children with FMF receiving regular colchicine, ranging in age from 3 to 16 years, were investigated in comparison with 15 healthy age- and sex-matched controls. The mean age of the patients was 9.7 +/- 3.9 years. Total nitrite, a stable product of NO, was quantitated by means of the Griess reaction, while AM was measured by HPLC. Results: Plasma-urinary AM and total nitrite levels were significantly higher in children with FMF. Plasma AM levels (pmol/mL) in patients and controls were 40.95 +/- 5.99 vs. 34.86 +/- 5.24, P < 0.05, and urinary AM excretion (pmol/mg creatinine) was 51.16 +/- 28.15 vs. 37.5 +/- 24.26, P < 0.05 respectively. Plasma total nitrite levels (mu mol/L) in patients and controls were 44.80 +/- 10.36 vs. 32.13 +/- 9.28, P < 0.05, and urinary nitrite excretion (mu mol/mg creatinine) was 2.24 +/- 1.71 vs. 1.09 +/- 0.96, P < 0.05 respectively. Conclusion: This study considered that AM and NO may have a role in the immuno-inflammatory process of FMF, although, whether these act to preserve, or protect against, further inflammatory injury is not clear. Our results further supports the hypothesis that these patients have subclinical inflammation between attacks.en_US
dc.identifier.doi10.1111/j.1440-1754.2006.00845.x
dc.identifier.endpage243en_US
dc.identifier.issn1034-4810
dc.identifier.issue5en_US
dc.identifier.pmid16712551en_US
dc.identifier.scopus2-s2.0-33646678221en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1754.2006.00845.x
dc.identifier.urihttps://hdl.handle.net/11616/94380
dc.identifier.volume42en_US
dc.identifier.wosWOS:000237515200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofJournal of Paediatrics and Child Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectfamilial Mediterranean feveren_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and total nitrite levels in children with familial Mediterranean feveren_US
dc.typeArticleen_US

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