Assessment of risk factors affecting mortality in patients with colorectal cancer

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridkale, ilhami taner/0000-0002-1522-8361
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidEmre, Arif/JME-3234-2023
dc.authorwosidkale, ilhami taner/C-8883-2014
dc.contributor.authorEmre, Arif
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSertkaya, Mehmet
dc.contributor.authorBitiren, Muharrem
dc.contributor.authorKale, Ilhami Taner
dc.contributor.authorBulbuloglu, Ertan
dc.date.accessioned2024-08-04T20:44:39Z
dc.date.available2024-08-04T20:44:39Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: The most important risk factors for colorectal cancer are age, high ASA score, anemia, low albumin, tumor stage, histopathological properties, tumor's relationship with adjacent tissues, positivity of surgical borders and timing of the surgical procedure. Aim: To determine possible risk factors for mortality in patients undergoing colorectal cancer surgery. Material and methods: The medical records of 101 consecutive patients who underwent colorectal cancer surgery at the Department of Surgery, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey between January 2008 and November 2015 were retrospectively reviewed. The patients were divided into two groups: surviving (n = 76) and deceased (n = 25) groups. The groups were compared in terms of several demographic, clinical, biochemical, and histopathological parameters. In addition, risk factors for mortality were analyzed with multivariate analysis. SPSS 22.2, PAST 3, and MedCalc 14 software packages were used for statistical analyses. Results: The surviving and deceased groups significantly differed with respect to age (p = 0.001), hemoglobin (p = 0.001), lymph node positivity (p = 0.009), positive lymph node/total lymph node ratio (p = 0.012), thrombocyte count (p = 0.047), lymphovascular invasion (p = 0.028), urgency of admission (emergency/elective) (p = 0.036), and postoperative carcinoembryonic antigen (CEA) level (p = 0.002). A receiver operating characteristics curve was drawn to determine the cut-off values of various parameters including age (63), hemoglobin (12.8), node positivity (3), positive/total lymph node ratio (0.435) and thrombocyte count (308), with age (p < 0.001), hemoglobin (p < 0.001), node positivity (p = 0.025) and positive/total lymph node ratio (p = 0.024) being significantly different. A multivariate analysis revealed that age (p = 0.049), hemoglobin (p = 0.045), and positive/total lymph node ratio (p = 0.025) were independent risk factors for mortality. Conclusions: This study shows that older age, lower hemoglobin level, and high positive/total lymph node ratio were independent risk factors for mortality among colorectal cancer patients.en_US
dc.identifier.doi10.5114/pg.2018.73348
dc.identifier.endpage117en_US
dc.identifier.issn1895-5770
dc.identifier.issn1897-4317
dc.identifier.issue2en_US
dc.identifier.pmid30002769en_US
dc.identifier.scopus2-s2.0-85049838744en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.5114/pg.2018.73348
dc.identifier.urihttps://hdl.handle.net/11616/98382
dc.identifier.volume13en_US
dc.identifier.wosWOS:000438120200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofGastroenterology Review-Przeglad Gastroenterologicznyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcolorectal canceren_US
dc.subjectmortalityen_US
dc.subjectrisk factorsen_US
dc.titleAssessment of risk factors affecting mortality in patients with colorectal canceren_US
dc.typeArticleen_US

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