Effect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind study

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridSanli, Mukadder/0000-0003-1009-5536
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.authorwosidSanli, Mukadder/ABI-8124-2020
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidErdogan, Mehmet Ali/ABI-7224-2020
dc.contributor.authorOzgul, U.
dc.contributor.authorBegec, Z.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorSanli, M.
dc.contributor.authorColak, C.
dc.contributor.authorDurmus, M.
dc.date.accessioned2024-08-04T20:37:45Z
dc.date.available2024-08-04T20:37:45Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection. This prospective, randomised, double-blind study included 300 adult, American Society of Anesthesiologists physcial status I to II patients undergoing elective surgery. Patients were randomly allocated to one of three groups: Group L received 0.05 ml/kg of 1% lignocaine (5 ml normal saline + 5 ml 2% lignocaine), Group A received 0.05 ml/kg alkalinised lignocaine (5 ml 2% lignocaine + 1 ml 8.4% NaHCO3 + 4 ml normal saline), and Group S, the control group, was given the same amount of normal saline (NaCl 0.9%). All drugs were given as a bolus over 20 seconds before propofol administration. A blinded researcher assessed the patient's pain level using a four-point scale. The pain score [median (range)] and the incidence of pain in Group A (6%) was significantly lower than in groups L (41%) and S (88%, P <0.001). In addition, the pain score and the incidence of pain were found to be significantly different between Group L and Group S (P <0.001). The incidence of moderate and severe pain were greater in Group S when compared with groups A and L (P <0.001). Intravenous pretreatment with alkalinised lignocaine appears to be effective in reducing the pain during propofol injection.en_US
dc.identifier.doi10.1177/0310057X1304100411
dc.identifier.endpage504en_US
dc.identifier.issn0310-057X
dc.identifier.issue4en_US
dc.identifier.pmid23808510en_US
dc.identifier.scopus2-s2.0-84881258385en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage501en_US
dc.identifier.urihttps://doi.org/10.1177/0310057X1304100411
dc.identifier.urihttps://hdl.handle.net/11616/96164
dc.identifier.volume41en_US
dc.identifier.wosWOS:000321320100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAustralian Soc Anaesthetistsen_US
dc.relation.ispartofAnaesthesia and Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlignocaine carbonateen_US
dc.subjectlignocaineen_US
dc.subjectpropofolen_US
dc.subjectpainen_US
dc.titleEffect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind studyen_US
dc.typeArticleen_US

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