Temporary Parenteral Tacrolimus Requirement due to Unexplained Low Through Levels in a Liver Transplant Patient with Short Bowel Syndrome

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridOzdemir, Fatih/0000-0003-0292-3602
dc.authoridYILMAZ, Mehmet/0000-0002-5710-5263
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authoridÖZDEMİR, FATİH/0000-0003-0292-3602
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidYilmaz, Mehmet/AAF-6095-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidOzdemir, Fatih/ABH-2875-2020
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidYILMAZ, Mehmet/HKM-4739-2023
dc.authorwosidIsik, Burak/A-6657-2018
dc.contributor.authorInce, V.
dc.contributor.authorOzdemir, F.
dc.contributor.authorIsik, B.
dc.contributor.authorYilmaz, M.
dc.contributor.authorKayaalp, C.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2024-08-04T20:38:02Z
dc.date.available2024-08-04T20:38:02Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAn adequate level of tacrolimus in serum should be obtained to prevent acute rejection following liver transplantation. Because of good gastrointestinal absorption of oral tacrolimus, adequate trough levels can be achieved even in patients with short bowel syndrome. Rarely, adequate through levels cannot be obtained by oral administration of the drug for several reasons such as inadequate absorption, having a discordant patient, laboratory error, and/or interactions with other drugs and foods. Here, we described a 16-year-old patient who had undergone massive intestinal resection due to mesenteric torsion 5 years previously and required liver transplantation for cryptogenic cirrhosis. Her remnant small bowel length was 90 cm. After a successful living donor liver transplantation, oral tacrolimus administration resulted in inadequate through levels in some parts of the postoperative period. We checked up all the potential reasons but could not identify any cause. An intravenous tacrolimus including immunosuppressive regimen was temporarily required. She maintained adequate blood levels of tacrolimus by parenteral route for a while; thereafter, oral administration resulted in enough blood drug levels. She was discharged with oral tacrolimus therapy. We concluded that very rarely, adequate blood levels of tacrolimus cannot be achieved by oral administration for unexplained reasons. In such cases, temporary administration of parenteral tacrolimus can be life-saving.en_US
dc.identifier.endpage42en_US
dc.identifier.issn2008-6490
dc.identifier.issn2008-6482
dc.identifier.issue1en_US
dc.identifier.pmid25013677en_US
dc.identifier.scopus2-s2.0-84893369037en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://hdl.handle.net/11616/96335
dc.identifier.volume5en_US
dc.identifier.wosWOS:000219271000006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvicenna Organ Transplant Centeren_US
dc.relation.ispartofInternational Journal of Organ Transplantation Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTacrolimusen_US
dc.subjectLiving donoren_US
dc.subjectLiver transplantationen_US
dc.subjectShort bowel syndromeen_US
dc.subjectimmunosuppressive agenten_US
dc.titleTemporary Parenteral Tacrolimus Requirement due to Unexplained Low Through Levels in a Liver Transplant Patient with Short Bowel Syndromeen_US
dc.typeArticleen_US

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