Prophylactic intravenous immunoglobulin use in allogeneic stem cell transplantation; does intravenous immunoglobulin affect survival, sepsis, and engraftment time?

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dc.contributor.authorKaya, Ahmet
dc.contributor.authorBerber, Ilhami
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorBicim, Soykan
dc.contributor.authorArslan, Suleyman
dc.date.accessioned2026-04-04T13:30:52Z
dc.date.available2026-04-04T13:30:52Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBACKGROUND:Stem cell transplant recipients have an increase in various infections depending on the immunosuppression. The purpose is to explore the effect of the use of proflact & imath;c intravenous immunoglobulin (IVIG) on transplant rec & imath;p & imath;ents. OBJECTIVE:It was aimed to examine the effect of IVIG on allogeneic stem cell transplantation. MATERIALS AND METHODS:In this study, sepsis status, infection focus causing sepsis, neutrophil and platelet engraftment time of patients the length of stay in the hospital at the time of the stem cell transplant, if the patient died, how many days after the transplant the event developed, and the data of the bone marrow transplant unit were reviewed retrospectively. One hundred and eleven patients who were given IVIG (400 mg/kg/week IVIG intravenous was given to the patients as a weekly prophylactic up to 100 days starting on the 7th day after transplantation) and 190 patients who did not receive IVIG were included in the study. RESULTS:There was no statistically significant difference between the IVIG groups in terms of gender, diagnosis, donor characteristics, and event (P > 0.05). Sepsis was observed significantly less in patients who were given IVIG compared to patients who were not given IVIG (P < 0.001). While it was observed that IVIG did not have a significant effect on platelet engraftment and discharge times (P > 0.05), neutrophil engraftment time was significantly higher in patients given IVIG compared to patients not given IVIG (P < 0.009). It was observed that the use of IVIG in patients with sepsis did not have a positive effect on survival. (with sepsis hazard ratio [HR]: 3.890 P = 0.001, IVIG given HR: 3.244 P = 0.035). CONCLUSION:It was observed that the use of IVIG in allogeneic stem cell transplantation was associated with a decrease in sepsis, but the use of IVIG did not have a positive effect on survival and could prolong neutrophil engraftment.
dc.identifier.doi10.4103/ijh.ijh_41_24
dc.identifier.endpage207
dc.identifier.issn2072-8069
dc.identifier.issn2543-2702
dc.identifier.issue2
dc.identifier.orcid0000-0003-3312-8476
dc.identifier.orcid0000-0001-8605-8497
dc.identifier.orcid0000-0002-3285-417X
dc.identifier.orcid0000-0002-9848-7958
dc.identifier.scopus2-s2.0-105012632806
dc.identifier.scopusqualityN/A
dc.identifier.startpage202
dc.identifier.urihttps://doi.org/10.4103/ijh.ijh_41_24
dc.identifier.urihttps://hdl.handle.net/11616/108435
dc.identifier.volume13
dc.identifier.wosWOS:001381994100010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIraqi Journal of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectEngraftment
dc.subjectintravenous immunoglobulin
dc.subjectsepsis
dc.subjectsurvival
dc.titleProphylactic intravenous immunoglobulin use in allogeneic stem cell transplantation; does intravenous immunoglobulin affect survival, sepsis, and engraftment time?
dc.typeArticle

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