Novel 2-methylimidazolium salts: Synthesis, characterization, molecular docking, and carbonic anhydrase and acetylcholinesterase inhibitory properties

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridsağlamtaş, rüya/0000-0002-4400-2302
dc.authoridKaraman, Muhammet/0000-0002-0155-3390
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidsağlamtaş, rüya/ABC-8186-2021
dc.authorwosidKaraman, Muhammet/AAG-4541-2019
dc.authorwosidkaya, rüya/AAB-2401-2021
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.contributor.authorBal, Selma
dc.contributor.authorKaya, Ruya
dc.contributor.authorGok, Yetkin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAktas, Aydin
dc.contributor.authorKaraman, Muhammet
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:46:59Z
dc.date.available2024-08-04T20:46:59Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this work, structures of different imidazolium compounds were designed and synthesized. These compounds were synthesized from 2-methylimidazole and alkyl/aryl halides. Their structures were characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopic techniques. All the synthesized compounds were tested for their inhibition activities on different enzymes. Inhibition experiments gave good and moderate results, proving their activities of these compounds as anticholinergics potential. These obtained novel 2-methylimidazolium salts (1a-e and 2a-e) molecules were effective inhibitors of the carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (AChE) enzymes with Ki values in the range of 26.45 +/- 6.49-77.60 +/- 9.53 nM for hCA I, 27.87 +/- 5.00-86.61 +/- 5.71 nM for hCA II, and 1.15 +/- 0.19-8.89 +/- 0.49 nM for AChE, respectively. AChE enzyme inhibitors are the most common drugs applied in the therapy of diseases such as senile dementia, Alzheimer's disease, ataxia, Parkinson's disease, and among others.en_US
dc.identifier.doi10.1016/j.bioorg.2019.103468
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.pmid31791684en_US
dc.identifier.scopus2-s2.0-85075947100en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.103468
dc.identifier.urihttps://hdl.handle.net/11616/99087
dc.identifier.volume94en_US
dc.identifier.wosWOS:000505596300115en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofBioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectImidazolium salten_US
dc.subjectMolecular dockingen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectAcetylcholinesteraseen_US
dc.titleNovel 2-methylimidazolium salts: Synthesis, characterization, molecular docking, and carbonic anhydrase and acetylcholinesterase inhibitory propertiesen_US
dc.typeArticleen_US

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