Relationship between reticular fibrosis with platelet surface markers (CD41A, CD42A, CD42B, CD61) and prognostic markers (WBC, PLT) in acute promyelocytic leukemia

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dc.contributor.authorKaya, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBerber, Ilhami
dc.contributor.authorSarici, Ahmet
dc.contributor.authorBozdag, Zehra
dc.date.accessioned2026-04-04T13:30:41Z
dc.date.available2026-04-04T13:30:41Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractIntroduction: Acute promyelocytic leukemia is a type of leukemia in which abnormal promyelocytes predominate in the peripheral blood and bone marrow. Its clinical course and treatment differ from those of other acute myeloid leukemias. It is necessary to elucidate bone marrow fibrosis in acute promyelocytic leukemia. Material and methods: Our study included 44 patients who were followed up and treated for acute promyelocytic leukemia in the adult hematology clinic of Turgut Ozal Medical Center, Malatya, Turkiye. The relationship between CD 41A, CD 42A, CD 42B, and CD61 levels in flow cytometry and prognostic markers (WBC, PLT) was studied at diagnosis, and the fibrosis grade in the bone marrow pathology taken at diagnosis was examined. Results: The relationship between the fibrosis grade in bone marrow biopsy at diagnosis and PLT, WBC, CD41A, CD42A, CD42B and CD61 values was statistically insignificant (p >0.05). There was no statistical difference between genders according to fibrosis results in bone marrow biopsy at diagnosis (p >0.05). There was a statistically significant age difference (p <0.05). At the time of diagnosis, the bone marrow fibrosis grade of 12 patients was found to be 2 or higher. We observed an increase in the fibrosis grade in bone marrow in three patients, a decrease in fibrosis in five patients, and no change in the fibrosis grade in six patients after treatment. There was no relationship between platelet surface markers and risk groups during the diagnosis of acute promyelocytic leukemia. While no correlation was detected between disseminated intravascular coagulation and platelet surface markers after treatment, a negative correlation was observed with pre-treatment INR. Conclusions: Reticular fibrosis may be seen in patients diagnosed with acute promyelocytic leukemia. The cause of reticular fibrosis is unclear. Elevation of flow cytometric platelet surface markers in blasts at diagnosis are not directly related to reticular fibrosis. There are conflicting results in the regression of reticular fibrosis after treatment.
dc.identifier.doi10.5603/ahp.99939
dc.identifier.endpage259
dc.identifier.issn0001-5814
dc.identifier.issn2300-7117
dc.identifier.issue5
dc.identifier.orcid0000-0003-3312-8476
dc.identifier.orcid0000-0002-3285-417X
dc.identifier.scopus2-s2.0-85210742815
dc.identifier.scopusqualityQ3
dc.identifier.startpage252
dc.identifier.urihttps://doi.org/10.5603/ahp.99939
dc.identifier.urihttps://hdl.handle.net/11616/108297
dc.identifier.volume55
dc.identifier.wosWOS:001598502500005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofActa Haematologica Polonica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectacute promyelocytic leukemia
dc.subjectreticular fibrosis
dc.subjectplatelet surface markers
dc.subjectflow cytometry
dc.titleRelationship between reticular fibrosis with platelet surface markers (CD41A, CD42A, CD42B, CD61) and prognostic markers (WBC, PLT) in acute promyelocytic leukemia
dc.typeArticle

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