Maternal and fetal serum orexin-A levels in gestational diabetes mellitus

dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridMinareci, Yagmur/0000-0003-1420-9318
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidMinareci, Yagmur/AAJ-7114-2021
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorCelik, Onder
dc.contributor.authorCelik, Nilufer
dc.contributor.authorCelik, Ebru
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorMinareci, Yagmur
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Evidence suggests that orexin regulates food consumption, glucose metabolism and insulin secretion. Orexin may have a role in the pathogenesis of type II diabetes mellitus, however its role in gestational diabetes mellitus is not known. We aimed to assess maternal serum and cord blood orexin-A (OXA) concentrations in pregnant women with gestational diabetes mellitus (GDM). Material and Methods: Thirty-five pregnant women with GDM and 35 gestational-age-matched healthy pregnant subjects participated in the study. Maternal serum and cord blood OXA levels were measured with enzyme immunoassay at the time of birth. The correlations between maternal serum and cord blood OXA levels, anthropometric and metabolic parameters were also assessed. Results: The mean maternal and cord serum OXA (1.16 +/- 0.37 and 1.35 +/- 0.20 ng/mL, respectively) in the GDM group were significantly different from those of the controls (1.58 +/- 0.59 and 1.25 +/- 0.21 ng/mL, respectively). The mean maternal fasting-glucose-to-OXA ratio was significantly higher in the GDM group. In the GDM group, the mean maternal serum OXA levels were similar in the insulin (n = 24) and diet (n = 11) treated cases, respectively (1.13 +/- 0.36 ng/mL and 1.21 +/- 0.41 ng/mL). Maternal serum OXA levels positively correlated with fetal serum OXA and maternal glucose levels. OXA concentrations in maternal serum were negatively correlated with the fasting glucose, fasting insulin and homeostasis model assessment insulin resistance index. Conclusions: Maternal serum OXA levels decrease, and fetal serum OXA levels increase in women with GDM.en_US
dc.identifier.doi10.1111/j.1447-0756.2012.01955.x
dc.identifier.endpage145en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue1en_US
dc.identifier.pmid22889404en_US
dc.identifier.scopus2-s2.0-84875704631en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2012.01955.x
dc.identifier.urihttps://hdl.handle.net/11616/96000
dc.identifier.volume39en_US
dc.identifier.wosWOS:000313250800020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcord blooden_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectglucoseen_US
dc.subjectHOMA-IRen_US
dc.subjectorexin-Aen_US
dc.titleMaternal and fetal serum orexin-A levels in gestational diabetes mellitusen_US
dc.typeArticleen_US

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