Maternal serum and amniotic fluid hydroxyproline levels in neural tube defects

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridRipszky-Totan, Alexandra/0000-0002-4345-282X;
dc.authorwosidTOTAN, ALEXANDRA/AAK-1950-2020
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidRipszky-Totan, Alexandra/JTT-4320-2023
dc.authorwosidTotan, Alexandra/AAY-6135-2021
dc.contributor.authorÖzyurt, H
dc.contributor.authorTotan, A
dc.contributor.authorSahin, S
dc.contributor.authorKilinç, C
dc.contributor.authorSögüt, S
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:13:22Z
dc.date.available2024-08-04T20:13:22Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The present study was aimed to evaluate the alterations of maternal serum and amniotic fluid OH-proline levels in neural tube defects (NTD). Methods: 38 patients and 23 control subjects were selected from the patients followed up by the Departments of Genetics and Antenatal Care, Zekai Tahir Burak Women's Health, Education and Research Hospital. Amnion fluid and blood samples were synchronously obtained from NTD and control subjects. OH-proline levels were detected spectrophotometrically. Results: Amniotic fluid CH-proline levels were found to be increased in NTID patients compared to control subjects (p < 0.05). There was no statistically significant difference in serum OH-proline levels between the groups. Conclusion: The results showed an increase in amniotic fluid OH-proline levels in NTD compared to the control group. It may be suggested that the increased OH-proline levels reflect increased collagen turnover in NTD patients. Indeed, amniotic fluid OH-proline levels may be a candidate as an additional diagnostic parameter in NTD. Copyright (C) 2003 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000071973
dc.identifier.endpage323en_US
dc.identifier.issn1015-3837
dc.identifier.issn1421-9964
dc.identifier.issue5en_US
dc.identifier.pmid12913341en_US
dc.identifier.scopus2-s2.0-0041660697en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1159/000071973
dc.identifier.urihttps://hdl.handle.net/11616/93583
dc.identifier.volume18en_US
dc.identifier.wosWOS:000184902400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofFetal Diagnosis and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneural tube defectsen_US
dc.subjectOH-prolineen_US
dc.subjectamniotic fluiden_US
dc.subjectmaternal serumen_US
dc.titleMaternal serum and amniotic fluid hydroxyproline levels in neural tube defectsen_US
dc.typeArticleen_US

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