Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:35:44Z
dc.date.available2024-08-04T20:35:44Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSeveral studies have well confirmed the contribution of oxidative stress in the pathogenesis of methotrexate (MTX)-induced damage in the various organs. Many agents have been tested experimentally to reduce or inhibit the oxidative stress. The aim of this study was to determine the possible protective effect of chlorogenic acid (CLG) on MTX-induced cerebellar damage in rats. The rats were randomly divided into three groups as follows: I: control group; II: MIX group; Ill: CLG + MIX group. In the MIX group; malondialdehyde (MDA) content was found to be increased, whereas superoxide dismutase (SOD), catalase (CAT) activities, and glutathione (GSH) content were decreased. On the other hand, CLG markedly attenuated the elevated MDA content and prevented the deleterious effects of MIX on oxidative stress markers. MIX caused severe loss of Purkinje cells and apoptotic cell death in the cerebellum. The CLG administration before MTX treatment significantly reduced Purkinje cell damage and the expression of apoptotic cells. In conclusion, our results demonstrate that chlorogenic acid treatment may protect the impairment of oxidative stress and ameliorate MIX-induced cerebellar damage at biochemical and histological levels. (C) 2011 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jchemneu.2011.09.003
dc.identifier.endpage47en_US
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.issue1en_US
dc.identifier.pmid21946024en_US
dc.identifier.scopus2-s2.0-84856515507en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2011.09.003
dc.identifier.urihttps://hdl.handle.net/11616/95556
dc.identifier.volume43en_US
dc.identifier.wosWOS:000301805600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPurkinje cellen_US
dc.subjectCaspase-3en_US
dc.subjectApoptosisen_US
dc.subjectMTXen_US
dc.subjectRaten_US
dc.titleBeneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in ratsen_US
dc.typeArticleen_US

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