Synthesis, characterization, DNA binding and anticancer activities of the imidazolidine-functionalized (NHC)Ru(II) complexes

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dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridFadhilah, Araniy/0000-0002-0412-5738
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.contributor.authorGurses, Canbolat
dc.contributor.authorAktas, Aydin
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorFadhilah, Araniy
dc.contributor.authorGok, Yetkin
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:50:37Z
dc.date.available2024-08-04T20:50:37Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHere, we present a study on the synthesis and biological properties of the ruthenium complexes having naphthyl substituted NHC ligands, which are of great importance for drug development studies. For this purpose, in our study, imidazolidine-functionalized Ru(II)NHC complexes containing naphthyl substitute group were synthesized and in vitro anticancer activity as well as DNA binding properties using agarose gel electrophoresis and ethidium bromide fluorescence quenching assay methods were determined in order to understand the biological activities. The Ru(II)NHC complexes were prepared from naphthyl-substituted Ag(I)NHC complexes and [RuCl2(p-cymene)](2) via the transmetallation method. These new complexes were characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopic method and elemental analysis techniques. Consequently, complex 1d showed the highest anticancer activity in terms of IC30 and IC50 values against HepG2 cell line as 23.9 and 32.84 mu M, respectively. Moreover, depending on the data obtained from agarose gel electrophoresis and fluorescence spectrophotometry techniques, 1b had the highest DNA binding property, which means that 1b behaved binding DNA in the cell as an intercalative manner rather than disrupting the integrity of cell membrane like 1d (C) 2021 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund [IUBAP FBG-2018-1569]en_US
dc.description.sponsorshipThis work was financially supported byInonu University Research Fund (IUBAP FBG-2018-1569). The authors acknowledge Inonu University Scientific and Technology Center for the elemental analyses of the compounds and the authors acknowledge Inonu University Faculty of Science Department of Chemistry for the characterization of compounds.en_US
dc.identifier.doi10.1016/j.molstruc.2021.131350
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85113998265en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.131350
dc.identifier.urihttps://hdl.handle.net/11616/100178
dc.identifier.volume1247en_US
dc.identifier.wosWOS:000704359900006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbenesen_US
dc.subjectRutheniumen_US
dc.subjectAnticancer activityen_US
dc.subjectDNA bindingen_US
dc.subjectFluorescence spectrophotometryen_US
dc.subjectAgarose gel electrophoresisen_US
dc.titleSynthesis, characterization, DNA binding and anticancer activities of the imidazolidine-functionalized (NHC)Ru(II) complexesen_US
dc.typeArticleen_US

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