Remifentanil and propofol for tracheal intubation without muscle relaxant in children: the effects of ketamine

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dc.authoridErdil, Feray Akgül/0000-0002-7544-3717
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.contributor.authorBegec, Zekine
dc.contributor.authorDemirbilek, Semra
dc.contributor.authorOzturk, Erdogan
dc.contributor.authorErdil, Feray
dc.contributor.authorErsoy, M. Ozcan
dc.date.accessioned2024-08-04T20:31:11Z
dc.date.available2024-08-04T20:31:11Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective Remifentanil and propofol have been proposed for intubation without muscle relaxant to avoid the adverse effects of muscle relaxants in children. We hypothesized that the addition of ketamine to remifentanil and propofol would improve intubating conditions and provide haemodynamic stability. Methods We studied 88 children (3-12 years) undergoing elective surgery. Group K received ketamine 0.5 mg kg(-1), remifentanil 3 mu g kg(-1) and propofol 3 mg kg(-1). Group C received isotonic saline instead of ketamine, all other study drugs were same as in group K. Sixty seconds after administration of propofol, laryngoscopy and tracheal intubation were performed. Intubating conditions were graded. Mean arterial pressure (MAP), heart rate (HR) and SPO2 were recorded. Results The intubating conditions were regarded as clinically acceptable in 39 out of 44 (89%) children in group K and in 36 out of 44 (82%) children in group C. Although there was no failed intubation in group K, the intubation failed in six children in group C (P<0.05). Tracheal intubation failed in 4/6 children because of severe coughing and/or limb movement, and in 2/6 children because of closed vocal cords. Scores for limb movement were significantly lower in group K than in group C. When compared with baseline, HR and MAP significantly decreased in both groups during the study (P<0.05). Conclusion The addition of ketamine to remifentanil and propofol prevented failed intubation and slightly increased the percentage of acceptable intubating conditions. Ketamine had no influence on haemodynamic changes following remifentanil and propofol administration in given doses. Eur J Anaesthesiol 26:213-217 (C) 2009 European Society of Anaesthesiology.en_US
dc.identifier.doi10.1097/EJA.0b013e328320a666
dc.identifier.endpage217en_US
dc.identifier.issn0265-0215
dc.identifier.issn1365-2346
dc.identifier.issue3en_US
dc.identifier.pmid19244696en_US
dc.identifier.scopus2-s2.0-65349170089en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1097/EJA.0b013e328320a666
dc.identifier.urihttps://hdl.handle.net/11616/94791
dc.identifier.volume26en_US
dc.identifier.wosWOS:000264308600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectketamineen_US
dc.subjectpropofolen_US
dc.subjectremifentanilen_US
dc.subjecttracheal intubationen_US
dc.titleRemifentanil and propofol for tracheal intubation without muscle relaxant in children: the effects of ketamineen_US
dc.typeArticleen_US

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