Effects of Rifaximin on Bacterial Translocation in Thioacetamide-Induced Liver Injury in Rats

Basit Öğe Kaydı
dc.authoridSelçuk, Engin Burak/0000-0001-8484-0223
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidSelçuk, Engin Burak/AAR-7556-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidGürsoy, Şule/JPW-8593-2023
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorHarputluoglu, Murat M. M.
dc.contributor.authorDemirel, Ulvi
dc.contributor.authorGul, Mehmet
dc.contributor.authorTemel, Ismail
dc.contributor.authorGursoy, Sule
dc.contributor.authorSelcuk, Engin Burak
dc.contributor.authorAladag, Murat
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntestinal bacterial overgrowth (IBO) and increased mucosal permeability are suggested to increase bacterial translocation (BT) in liver injury. Rifaximin (RIF) is a minimally absorbed oral antimicrobial agent that restores gut microflora imbalance. The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA + RIF), RIF was commenced on the same day as the first dose of TAA. In group 4 (RIF), rats received only RIF. Ileal aspirate Escherichia coli counts were significantly lower in the TAA + RIF group than in TAA group. There was no difference in BT frequency between the TAA and TAA + RIF groups. Our results suggest that factors such as intestinal barrier dysfunction and impaired host immune shield, apart from IBO, play an important role in BT in this model.en_US
dc.identifier.doi10.1007/s10753-012-9465-2
dc.identifier.endpage1517en_US
dc.identifier.issn0360-3997
dc.identifier.issue4en_US
dc.identifier.pmid22527146en_US
dc.identifier.scopus2-s2.0-84866740450en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1512en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-012-9465-2
dc.identifier.urihttps://hdl.handle.net/11616/95809
dc.identifier.volume35en_US
dc.identifier.wosWOS:000306547400034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrifaximinen_US
dc.subjectbacterial translocationen_US
dc.subjectthioacetamideen_US
dc.subjectliver injuryen_US
dc.titleEffects of Rifaximin on Bacterial Translocation in Thioacetamide-Induced Liver Injury in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu