The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridÖĞÜT, ZEKİ/0000-0002-7698-9586
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidÖĞÜT, ZEKİ/IZP-6632-2023
dc.authorwosidSAHIN, TEVFIK TOLGA/W-2539-2017
dc.contributor.authorDalda, Yasin
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorTuncer, Adem
dc.contributor.authorOgut, Zeki
dc.contributor.authorSatilmis, Basri
dc.contributor.authorDalda, Ozlem
dc.date.accessioned2024-08-04T20:55:56Z
dc.date.available2024-08-04T20:55:56Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Objectives: The aim of this study is to evaluate the clinical and laboratory changes of ischemia and reperfusion injury in the remnant livers of donors with and without Pringle maneuver. Furthermore, we evaluated the recipients who have been transplanted with liver grafts from these donors. Methods and Materials: A total of 108 patients (54 living liver donors and 54 liver recipients) who underwent donor hepatectomy and recipients who living donor liver transplantation, were included in this randomized double-blind study between February 2021 and June 2021. The donors were divided into two groups: Pringle maneuver applied (n = 27) and Pringle maneuver not applied (n = 27). Similarly, recipients with implanted liver obtained from these donors were divided into two groups as the Pringle maneuver was performed (n = 27) and not performed (n = 27). Blood samples from donors and recipients were obtained on pre-operative, post-operative 0 h day (day of surgery), post-operative 1st day, post-operative 2nd day, post-operative 3rd day, post-operative 4th day, post-operative 5th day, and liver tissue was taken from the graft during the back table procedures. Liver function tests and complete blood count, coagulation tests, IL-1, IL-2, IL-6, TNF-alpha, and beta-galactosidase measurements, and histopathological findings were examined. Results: There was no statistically significant difference in the parameters of biochemical analyses for ischemia-reperfusion injury at all periods in the donors with and without the Pringle maneuver. Similarly, there was no statistically significant difference between in the recipients in who received liver grafts harvested with and without the Pringle maneuver. There was no statistically significant difference between the two recipient groups in terms of perioperative bleeding and early bile duct complications (p = 0.685). In the histopathological examinations, hepatocyte damage was significantly higher in the Pringle maneuver group (p = 0.001). Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.en_US
dc.description.sponsorshipInonu Universityen_US
dc.description.sponsorshipWe would like to commend all healthcare professionals who were always on the frontline. They took the courage and responsibility of treating all patients during these hard times despite risking their own lives. They are real heroes.en_US
dc.identifier.doi10.3390/medicina60040649
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue4en_US
dc.identifier.pmid38674295en_US
dc.identifier.scopus2-s2.0-85191299447en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/medicina60040649
dc.identifier.urihttps://hdl.handle.net/11616/101949
dc.identifier.volume60en_US
dc.identifier.wosWOS:001210641500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliver transplantationen_US
dc.subjectPringle maneuveren_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectliving liver donorsen_US
dc.subjectrecipientsen_US
dc.subjectimmune responseen_US
dc.subjectinflammatory responseen_US
dc.titleThe Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipientsen_US
dc.typeArticleen_US

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