Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidCenesiz, Sena/HJJ-1574-2023
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorCenesiz, S.
dc.contributor.authorYarim, G. F.
dc.contributor.authorKarabulut, A. B.
dc.contributor.authorAra, C.
dc.date.accessioned2024-08-04T20:30:38Z
dc.date.available2024-08-04T20:30:38Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects.en_US
dc.identifier.doi10.2377/0341-6593-114-345
dc.identifier.endpage348en_US
dc.identifier.issn0341-6593
dc.identifier.issue9en_US
dc.identifier.pmid17927075en_US
dc.identifier.scopus2-s2.0-37349117985en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.2377/0341-6593-114-345
dc.identifier.urihttps://hdl.handle.net/11616/94416
dc.identifier.volume114en_US
dc.identifier.wosWOS:000249805600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherM H Schaper Gmbh Co Kgen_US
dc.relation.ispartofDeutsche Tierarztliche Wochenschriften_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbile duct ligationsen_US
dc.subjectbiliary cirrhosisen_US
dc.subjectfibrosisen_US
dc.subjectoxidative stressen_US
dc.subjectresveratrolen_US
dc.titleChanging of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrolen_US
dc.typeArticleen_US

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