Thiol/Disulfide Homeostasis in Patients with Central Serous Chorioretinopathy

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dc.authoridAlisik, Murat/0000-0003-0434-3206
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridBiçer, cemile/0000-0001-7937-4475;
dc.authorwosidAlisik, Murat/O-6114-2019
dc.authorwosiddikci, seyhan/A-3311-2019
dc.authorwosidEREL, Ozcan/U-1008-2019
dc.authorwosidBiçer, cemile/HJZ-2656-2023
dc.authorwosidbiçer, cemile/HQZ-5043-2023
dc.contributor.authorTurkoglu, Elif Betul
dc.contributor.authorDikci, Seyhan
dc.contributor.authorCelik, Erkan
dc.contributor.authorErel, Ozcan
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorAlisik, Murat
dc.contributor.authorKoca, Cemile
dc.date.accessioned2024-08-04T20:41:37Z
dc.date.available2024-08-04T20:41:37Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To evaluate dynamic thiol/disulfide homeostasis in patients with chronic central serous chorioretinopathy (cCSC).Methods: This prospective study included 34 cCSC cases and 37 healthy individuals who were age- and sex-matched. A new colorimetric method for measuring thiol/disulfide homeostasis was used. Native thiol, total thiol/disulfide levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were measured.Results: The age and gender distributions were similar in both main groups. The mean duration of disease was 47.29 24 months. Native and total thiol levels were significantly lower among the cCSC group relative to the control group (p < 0.001). There was not a statistically significant difference between the cCSC and the control group in terms of disulfide levels (p = 0.492). While disulfide/native thiol and disulfide/total thiol ratios were elevated, the native thiol/total thiol ratio was decreased in the cCSC group (p = 0.017, 0.021, 0.036, respectively). Ratios obtained using plasma native thiol, total thiol, and disulfide levels differed significantly between the both groups.Conclusion: Disulfide/thiol ratio was significantly greater in cCSC patients relative to healthy control subjects. Our results suggest that the oxidative process is involved in the pathogenesis of the cCSC.en_US
dc.identifier.doi10.3109/02713683.2015.1127390
dc.identifier.endpage1491en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue11en_US
dc.identifier.pmid27002242en_US
dc.identifier.scopus2-s2.0-84961393369en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1489en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2015.1127390
dc.identifier.urihttps://hdl.handle.net/11616/97233
dc.identifier.volume41en_US
dc.identifier.wosWOS:000387928300015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectautomated quantitationen_US
dc.subjectmercaptanen_US
dc.subjectoxidative stressen_US
dc.subjectretinaen_US
dc.titleThiol/Disulfide Homeostasis in Patients with Central Serous Chorioretinopathyen_US
dc.typeArticleen_US

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