Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridSayan, Muhammet/0000-0002-5402-9031
dc.authoridAtilla, Nurhan/0000-0003-4127-4924
dc.authoridAydemir, Yusuf/0000-0003-2479-2949
dc.authoridPOLAT, Cemal/0000-0002-1587-3934
dc.authoridCakir, Tugrul/0000-0001-7952-8462
dc.authorwosidSayan, Muhammet/P-5133-2019
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidSayan, Muhammet/N-6267-2018
dc.authorwosidAtilla, Nurhan/W-4611-2017
dc.authorwosidÇakır, Tuğrul/AAD-1906-2019
dc.authorwosidAydemir, Yusuf/F-7334-2019
dc.authorwosidPolat, Cemal/AAX-9226-2020
dc.contributor.authorArpag, Huseyin
dc.contributor.authorGul, Mehmet
dc.contributor.authorAydemir, Yusuf
dc.contributor.authorAtilla, Nurhan
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorCakir, Tugrul
dc.contributor.authorPolat, Cemal
dc.date.accessioned2024-08-04T20:43:02Z
dc.date.available2024-08-04T20:43:02Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was performed with a single dose of MTX (20mg/kg) to groups 2 and 3. On the sixth day, animals in all groups were sacrificed by decapitation and lung tissue and blood samples were removed for histological examination and also measurement the levels of interleukin-1-beta (IL-1), malondialdehyde (MDA), glutathione (GSH), tumour necrosis factor-alpha (TNF-), myeloperoxidase (MPO), and sodium potassium-adenosine triphosphatase (Na+/K+ATPase). Results: In MTX group tissue GSH, Na+/K+ATPase activities were lower, tissue MDA, MPO and plasma IL-1?, TNF-? were significantly higher than the other groups. Histopathological examination showed that lung injury was less severe in group 2 according to group 3. Conclusions: Oxidative damage of MTX in rat lung is partially reduced when combined with ALA.en_US
dc.identifier.doi10.1080/08941939.2017.1296513
dc.identifier.endpage113en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue2en_US
dc.identifier.pmid28340320en_US
dc.identifier.scopus2-s2.0-85016088241en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2017.1296513
dc.identifier.urihttps://hdl.handle.net/11616/97751
dc.identifier.volume31en_US
dc.identifier.wosWOS:000427277200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlungen_US
dc.subjectoxidative stressen_US
dc.subjectalpha-lipoic aciden_US
dc.subjectmethotrexateen_US
dc.subjectraten_US
dc.subjectinjuryen_US
dc.titleProtective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Ratsen_US
dc.typeArticleen_US

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