Elements Levels and Glucose-6-Phosphate Dehydrogenase Activity in Blood of Patients with Schizophrenia

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dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridUnal, Suheyla/0000-0003-3266-6256;
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.contributor.authorKaya, Burhanettin
dc.contributor.authorAkdag, Nihal
dc.contributor.authorFadillioglu, Ersin
dc.contributor.authorTaycan, Serap Erdogan
dc.contributor.authorEmre, Mehmet H.
dc.contributor.authorUnal, Suheyla
dc.contributor.authorSayal, Ahmet
dc.date.accessioned2024-08-04T20:36:11Z
dc.date.available2024-08-04T20:36:11Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Glucose-6-phosphate dehydrogenase (G6PD) is the rate limiting enzyme of the hexose monophosphate cascade which plays role in the synthesis of nucleotide, reduced glutathion, fatty acid and cholesterol precursors. At the same time, it is an important enzyme for neuronal development during and after fetal life and for neurotransmitters. Serum elements are necessary for neuronal development and synthesis and activity of enzymes and hormones. The aim of this study was to compare serum levels of some elements and G6PD enzyme activity in schizophrenic patients with those in healthy individuals. Methods: This study involved blood serum analysis of 32 schizophrenia patients and 32 age-and sex-matched healthy controls. Copper, zinc, iron, magnesium levels were determined with a double lighted, deuterium sourced, background proof reading fire atomic spectrophotometer and in order to determine aluminum and manganese levels, a graphite tube atomizer spectroscope was used. G6PD enzyme activity was analyzed by the Glock and Mclean Method. Results: This analysis revealed higher levels of G6PD activity, copper, iron, magnesium and aluminum in schizophrenia patients compared to controls, whereas zinc and manganese levels showed a decreasing trend on the contrary. Discussion: The higher levels of G6PD activity in schizophrenic patients is not consistent with the literature in general. It is considered that results on G6PD and element levels may be explained as the effects of specific hormones, antipsychotic medications, or by schizophrenia itself. Conclusion: The elements we investigated and G6PD are important for the antioxidant system. Thus changing levels of elements in patients with schizophrenia may lead to disturbed functions of antioxidant enzymes and G6PD. Further researches on this subject conducted with larger and drug naive patient groups are needed.en_US
dc.identifier.doi10.5350/DAJPN2012250301
dc.identifier.endpage205en_US
dc.identifier.issn1018-8681
dc.identifier.issn1309-5749
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84867922414en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.5350/DAJPN2012250301
dc.identifier.urihttps://hdl.handle.net/11616/95830
dc.identifier.volume25en_US
dc.identifier.wosWOS:000421425900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofDusunen Adam-Journal of Psychiatry and Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectglucose-6-phosphate dehydrogenaseen_US
dc.subjectserum element levelen_US
dc.titleElements Levels and Glucose-6-Phosphate Dehydrogenase Activity in Blood of Patients with Schizophreniaen_US
dc.typeArticleen_US

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