Unveiling cardiac insights: Exploring early left ventricular dysfunction in polycythemia vera through 4D-STE and fragmented QRS analysis

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dc.authoridkarasu, mehdi/0000-0003-1713-3451
dc.authoridKaraca, Yücel/0000-0002-5184-5308
dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authorwosidkarasu, mehdi/ABK-4661-2022
dc.authorwosidKaraca, Yücel/AAA-4477-2022
dc.authorwosidulutas, zeynep/AAJ-8248-2020
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.contributor.authorKarasu, Mehdi
dc.contributor.authorBerber, Ilhami
dc.contributor.authorKaraca, Yuecel
dc.contributor.authorCansel, Mehmet
dc.contributor.authorUlutas, Zeynep
dc.date.accessioned2024-08-04T20:54:50Z
dc.date.available2024-08-04T20:54:50Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundPolycythemia vera (PV), characterized by elevated red blood cell counts, poses challenges to cardiovascular health with potential impacts on cardiac function. Myocardial infarction (MI) and heart failure are major causes of mortality in PV patients. Early detection of left ventricular systolic dysfunction is crucial for optimizing outcomes.MethodsFifty-two PV patients and 45 healthy controls were recruited. Four-dimensional speckle tracking echocardiography (4D-STE) and fragmented QRS complexes (fQRS) on electrocardiograms were utilized to assess cardiac mechanics. Hematological and echocardiographic parameters were measured, and statistical analyses were performed.ResultsPV patients exhibited significantly higher hematocrit and red cell distribution width compared to controls. Global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were lower in PV patients. fQRS complexes were associated with longer disease duration and reduced GCS and GAS values. Hematocrit correlated positively with LV-GCS and LV-GAS. Multiple linear regression revealed that disease duration and fQRS presence independently predicted LV-GAS.ConclusionThis study underscores the intricate link between elevated red blood cell counts, disease duration, and cardiac function in PV patients. Combining 4D-STE and fQRS complexes enhances the identification of early left ventricular systolic dysfunction. These findings offer potential improvements in recognizing and managing cardiovascular complications in PV patients, with implications for future research and clinical practice. Further investigations are needed to elucidate underlying mechanisms and validate these markers in larger cohorts.en_US
dc.description.sponsorshipI would like to thank all my colleagues mentioned in the article who contributed to the design of the study, data collection, data analysis and writing. The author(s) received no financial support for the research, authorship, and/or publication of this aren_US
dc.description.sponsorshipI would like to thank all my colleagues mentioned in the article who contributed to the design of the study, data collection, data analysis and writing. The author(s) received no financial support for the research, authorship, and/or publication of this article.en_US
dc.identifier.doi10.1111/echo.15715
dc.identifier.endpage1373en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue12en_US
dc.identifier.pmid37965911en_US
dc.identifier.scopus2-s2.0-85176922445en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1365en_US
dc.identifier.urihttps://doi.org/10.1111/echo.15715
dc.identifier.urihttps://hdl.handle.net/11616/101675
dc.identifier.volume40en_US
dc.identifier.wosWOS:001101283600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfour-dimensional speckle tracking echocardiographyen_US
dc.subjectfragmented QRS complexesen_US
dc.subjectpolycythemia veraen_US
dc.titleUnveiling cardiac insights: Exploring early left ventricular dysfunction in polycythemia vera through 4D-STE and fragmented QRS analysisen_US
dc.typeArticleen_US

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