Effects of total parenteral nutrition on renal function in preterm neonate

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dc.authoridÖncül, Mehmet/0000-0001-5874-7826
dc.authoridElmas, Ahmet Taner/0000-0002-9749-6115;
dc.authorwosidELMAS, Ahmet Taner/W-4101-2017
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidÖncül, Mehmet/ABV-4995-2022
dc.authorwosidElmas, Ahmet Taner/ABI-1338-2020
dc.authorwosidAKIN, Ilke Mungan/ABE-7061-2020
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorOncul, Mehmet
dc.contributor.authorAkin, Ilke Mungan
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorElmas, Ahmet Taner
dc.date.accessioned2024-08-04T20:37:22Z
dc.date.available2024-08-04T20:37:22Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of this study was to establish serum sistatine C, urine beta(2) microglobulin, gluthatione-S -transferase pi and N-acetyle beta-D glucosaminidase levels in order to evaluate the effect of total parenteral nutrition on renal function in premature infants. In addition, we aimed to compare the renal functions between premature infants receiving total parenteral nutrition and control groups receiving enteral feeding. Material and Method: A hundred four premature infants with a gestational age between 28 and 34 weeks were included in the study. The parenteral nutrition group consisted of 50 infants (male/female; 23/27 and mean weight 1258 +/- 212.3 g) and the enteral nutrition group consisted of 54 infants (male/female; 20/34 and mean weight 1608 +/- 206.1 g). In the parenteral nutrition group; total parenteral group nutrition was initiated on the 3rd day in the enteral nutrition group, minimal enteral nutrition was started on a mean of 6.3 +/- 2.4 days and total enteral nutrition was started on a mean of 24.5 +/- 6.3 days. Breastmilk was given orally or by orogastric/nasogastric tube at first day of life in the enteral group. On the 3rd and 30th day Of life, blood samples of all patients were obtained for evaluating biochemical parameters and cystatin C and urine samples were obtained for evaluation of N-acetyl beta-D glucosaminidase, gluthatione-S-transferase pi, beta(2) microglobulin, sodium, creatinin levels, density and pH of the urine. The study was approved by the ethics commite (2008/16). Results: When we compared the patients who received total parenteral nutrition and enteral nutrition on the 3rd and 30th days, serum cystatin C, urinary beta(2) microglobulin, gluthatione-S-transferase pi and N-acetyl- beta-D glucosaminidase excretions were similar on the 3rd day however were significantly higher on the 30th day in samples of the patients receiving total parenteral nutrition (p<0.05 for each parameter on each day). Conclusions: This study shows that total parenteral nutrition in premature infants can have adverse effects on glomerular and tubular functions of the kidney which can be manifested at an early time with cystatin C, beta(2) microglobulin, gluthatione-S-transferase pi and N-acetyl beta-D glucosaminidase. (Turk Arch Ped 2012; 47: 247-52)en_US
dc.identifier.doi10.4274/tpa.856
dc.identifier.endpage252en_US
dc.identifier.issn1306-0015
dc.identifier.issn1308-6278
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84871590672en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.4274/tpa.856
dc.identifier.urihttps://hdl.handle.net/11616/95898
dc.identifier.volume47en_US
dc.identifier.wosWOS:000313235200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Pediatrics Assocen_US
dc.relation.ispartofTurk Pediatri Arsivi-Turkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCystatin Cen_US
dc.subjectgluthatione-S-transferase pien_US
dc.subjectN-acetyl beta-D glucosaminidaseen_US
dc.subjectpretermen_US
dc.subjectrenal functionen_US
dc.subjecttotal parenteral nutritionen_US
dc.subjectbeta(2) microglobulinen_US
dc.titleEffects of total parenteral nutrition on renal function in preterm neonateen_US
dc.typeArticleen_US

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