Long-term beneficial effects of dexamethasone on intellectual and neuropsychological outcome of children with pneumococcal meningitis

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dc.authoridKARA, ATES/0000-0002-1654-3232
dc.authoridCengiz, Ali Bulent/0000-0002-2628-6954
dc.authoridOzen, Metehan/0000-0003-4088-3103
dc.authorwosidCENGIZ, ALI BULENT/I-9080-2013
dc.authorwosidBAKAR, EMEL ERDOĞAN/JEF-6606-2023
dc.authorwosidOzen, Metehan/X-2705-2018
dc.authorwosidKARA, ATES/I-9081-2013
dc.authorwosidOzen, Metehan/E-2610-2016
dc.contributor.authorOzen, M
dc.contributor.authorKanra, G
dc.contributor.authorKara, A
dc.contributor.authorBakar, EE
dc.contributor.authorCeyhan, M
dc.contributor.authorSecmeer, G
dc.contributor.authorCengiz, AB
dc.date.accessioned2024-08-04T20:15:14Z
dc.date.available2024-08-04T20:15:14Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA Substantial ratio of bacterial meningitis survivors suffers mild or serious intellectual and neuropsychological handicaps. We organized eighty subjects into three groups: 1) Pneumococcal meningitis ( PM) who did not receive dexamethasone, 2) PM who received dexamethasone, 3) Other bacterial meningitis with different etiology. All subjects underwent Bender Visual Motor Gestalt test and age-appropriate Intelligence qutient ( IQ) tests. The mean full-scale IQ scoring fell within normal range ( 90 +/- 17) in the post-meningitic cohort. There was no statistical difference between two pneumococcal groups regarding full scale IQ testing ( 88 +/- 16 and 91 +/- 18) and Bender-Gestalt scoring ( 4.0 +/- 3.3 and 3.8 +/- 2.6), respectively. However, the subjects with full scale IQ score < 85 ( below the average) were statistically less in the group with steroid therapy. PM patients who received dexamethasone therapy had statistically better academic performance. As a result, adjuvant steroid therapy has no significant impact on overall intellectual tests in PM subjects. However, dexamethasone seems to diminish development of below the average IQ scoring in PM cases. In addition, PM subjects who received steroids showed better academic achievement. These findings may support the idea of dexamethasone administration prior to first antibiotic dose in PM subjects.en_US
dc.identifier.doi10.1080/00365540500276005
dc.identifier.endpage109en_US
dc.identifier.issn0036-5548
dc.identifier.issn1651-1980
dc.identifier.issue2en_US
dc.identifier.pmid16449000en_US
dc.identifier.scopus2-s2.0-32144436425en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.1080/00365540500276005
dc.identifier.urihttps://hdl.handle.net/11616/94260
dc.identifier.volume38en_US
dc.identifier.wosWOS:000235002500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofScandinavian Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildhood Bacterial-Meningitisen_US
dc.subjectInfluenzae Meningitisen_US
dc.subjectHearing Impairmenten_US
dc.subjectTherapyen_US
dc.subjectHyperactivityen_US
dc.subjectDiagnosisen_US
dc.subjectDisorderen_US
dc.subjectSequelaeen_US
dc.titleLong-term beneficial effects of dexamethasone on intellectual and neuropsychological outcome of children with pneumococcal meningitisen_US
dc.typeArticleen_US

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