The effect of lidocaine infusion on neurocognitive dysfuction after cardiopulmonary bypass

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dc.authorscopusid55666804700
dc.authorscopusid6603931556
dc.authorscopusid6701613323
dc.authorscopusid7003374400
dc.authorscopusid34569135700
dc.authorscopusid7006384185
dc.authorscopusid7004486274
dc.contributor.authorIlksen Toprak H.
dc.contributor.authorTürköz A.
dc.contributor.authorTo?al T.
dc.contributor.authorÖzcan Y.
dc.contributor.authorDurmuş M.
dc.contributor.authorÖztürk E.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T19:59:42Z
dc.date.available2024-08-04T19:59:42Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough technically, surgical, and pharmacological research to prevent neuropsychological (NP) dysfunction are ongoing, NP dysfunction after cardiopulmonary bypass (CPB) is among the most important causes of postoperative morbidity and mortality. In recent years lidocaine, which has being investigated for being its effects on cerebral protection, showed many side effects on central nervous system even at clinical doses. In this study, we investigated whether lidocaine at clinical doses increase the disturbances on cognitive functions after CPB. Twenty-three cases enrolled in this study with coronary artery disease were divided into two groups randomly. Just after the pump, the first group (group I) was received 100 mg IV bolus of lidocaine and 1 mg min-1 lidocaine infusion, and the other group (group II) received same amounts of saline solution. Infusions were stopped at postoperative 24th hour. Cases were evaluated by a psychiatrist who does mot know the groups of patients for NP functions by Wechsler Memory Scale-Revised Form with seven subtests, one day before (ti), 24 hours after operation (ts) and at postoperative 7th day (tt). There was a significant decrease in score of two subtests evaluated at ts compared with ti in group I and it was observed that total NP function scores at ts were significantly decreased compared to ti. Whereas, in group II, there was a significant decrease in only one subtest and there was no significant difference in comparison of total scores. In addition, when two groups were compared, decrease in logical memory score and total NP function score at ts were more significant in group I than in group II. It was thought that lidocaine used after CPB could increase postoperative NP dysfunction. Nevertheless, a psychometric test with wider content should be used and we think that our results should be supported by other studies.en_US
dc.identifier.endpage143en_US
dc.identifier.issn1016-5150
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0037695075en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://hdl.handle.net/11616/90839
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectLidocaineen_US
dc.subjectNeuropsychological dysfunctionen_US
dc.titleThe effect of lidocaine infusion on neurocognitive dysfuction after cardiopulmonary bypassen_US
dc.title.alternativeKardiyopulmoner bypass sonrasinda görülen kognitif disfonksiyonlar üzerine lidokain infüzyonunun etkisien_US
dc.typeArticleen_US

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