Thymoquinone protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induced nephrotoxicity in rats

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dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidYigitcan, Birgul/KUD-3587-2024
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorGul, Semir
dc.date.accessioned2024-08-04T20:47:13Z
dc.date.available2024-08-04T20:47:13Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effects of thymoquinone (TQ) on kidney tissues of Wistar rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced nephrotoxicity. We used 50 rats divided into five groups; control, corn oil, TCDD, TQ, TCDD + TQ. We found that malondialdehyde (MDA), total oxidant status (TOS), blood urea nitrogen (BUN), creatinine, interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) levels in the TCDD treated group increased significantly compared to the other groups, while reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels decreased in the TCDD group. In the TQ treated group, we found that GSH, SOD, CAT, TAS levels increased and MDA, TOS, IL-6 and TNF-alpha levels decreased compared to the other groups. The effects of TCDD on oxidative stress parameters, inflammatory markers and histological changes were ameliorated by TQ treatment.en_US
dc.identifier.doi10.1080/10520295.2020.1735520
dc.identifier.endpage574en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue8en_US
dc.identifier.pmid32207631en_US
dc.identifier.scopus2-s2.0-85082404037en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage567en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1735520
dc.identifier.urihttps://hdl.handle.net/11616/99235
dc.identifier.volume95en_US
dc.identifier.wosWOS:000524689700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectkidneyen_US
dc.subjectnephrotoxicityen_US
dc.subjectoxidative stressen_US
dc.subject2en_US
dc.subject3en_US
dc.subject7en_US
dc.subject8-tetrachlorodibenzo-p-dioxinen_US
dc.subjectthymoquinoneen_US
dc.titleThymoquinone protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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