Protective effect of dexpanthenol on bleomycin-induced pulmonary fibrosis in rats

Basit Öğe Kaydı
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridErmis, Hilal/0000-0002-1764-9098
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridAytemur, Zeynep Ayfer/0000-0003-0421-907X
dc.authoridGulbas, Gazi/0000-0002-9435-8307
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidErmis, Hilal/ABI-2900-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidAytemur, Zeynep Ayfer/ABI-7452-2020
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorErmis, Hilal
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorGulbas, Gazi
dc.contributor.authorVardi, Nigar
dc.contributor.authorPolat, Alaadin
dc.contributor.authorCetin, Asli
dc.contributor.authorKilic, Talat
dc.date.accessioned2024-08-04T20:38:00Z
dc.date.available2024-08-04T20:38:00Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDespite extensive studies, there is no effective treatment currently available other than pirfenidone for idiopathic pulmonary fibrosis. A protective effect of pantothenic acid and its derivatives on cell damage produced by oxygen radicals has been reported, but it has not been tested in bleomycin (BLM)--induced pulmonary fibrosis in rats. Therefore, we aimed to investigate the preventive effect of dexpanthenol (Dxp) on pulmonary fibrosis. Thirty-two rats were assigned to four groups as follows: (1) control group, (2) dexpanthenol (Dxp) group; 500 mg/kg Dxp continued intraperitoneally for 14 days, (3) bleomycin (BLM) group; a single intratracheal injection of BLM (2.5 mg/kg body weight in 0.25-ml phosphate buffered saline), and (4) BLM + Dxp-treated group; 500 mg/kg Dxp was administered 1 h before the intratracheal BLM injection and continued for 14 days i.p. The histopathological grades of lung inflammation and collagen deposition, tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and myeloperoxidase (MPO) were measured. BLM provoked inflammation and collagen deposition (p < 0.0001), with a marked increase in myeloperoxidase (MPO) activity resembling increased inflammatory activity (p < 0.0001), which was prevented by Dxp (p < 0.0001, p = 0.02). BLM reduced tissue activities of SOD, GPx, and CAT compared to controls (p = 0.01, 0.03, 0.009). MDA was increased with BLM (p = 0.003). SOD (p = 0.001) and MDA (p = 0.016) levels were improved in group 4. The CAT levels in the BLM + Dxp group were close to those in the control group (p > 0.05). We showed that Dxp significantly prevents BLM-induced lung fibrosis in rats. Further studies are required to evaluate the role of Dxp in the treatment of lung fibrosis.en_US
dc.identifier.doi10.1007/s00210-013-0908-6
dc.identifier.endpage1110en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue12en_US
dc.identifier.pmid23995256en_US
dc.identifier.scopus2-s2.0-84889884768en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1103en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-013-0908-6
dc.identifier.urihttps://hdl.handle.net/11616/96300
dc.identifier.volume386en_US
dc.identifier.wosWOS:000327092100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectBleomycinen_US
dc.subjectPulmonary fibrosisen_US
dc.subjectIdiopathic pulmonary fibrosisen_US
dc.titleProtective effect of dexpanthenol on bleomycin-induced pulmonary fibrosis in ratsen_US
dc.typeArticleen_US

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