The effects of fibroblast growth factor-2 and ozone therapy on acute kidney injury in renal ischemia/reperfusion injury

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dc.authorscopusid55682450000
dc.authorscopusid55807973900
dc.authorscopusid14056834700
dc.authorscopusid36865963300
dc.authorscopusid57221529398
dc.authorscopusid8294895600
dc.contributor.authorBahar L.
dc.contributor.authorGul M.
dc.contributor.authorResitoglu B.
dc.contributor.authorCelik Y.
dc.contributor.authorErturk S.E.
dc.contributor.authorGul S.
dc.date.accessioned2024-08-04T20:00:38Z
dc.date.available2024-08-04T20:00:38Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRenal ischemia/reperfusion (I/R) injury is the most common risk factor for AKI. The study aimed to investigate the effects of FGF-2 and ozone applications on the kidneys of rats with hypoxic-ischemia. Six groups were formed with seven pups in each: sham control, ischemia-reperfusion (I/R), FGF-2(10-1/ml); FGF-2(20 ul/ml), ozone (25 mg/kg), and ozone (50 mg/kg) groups. After the tissue processing and staining of the kidney samples, the renal injury was scored and data were analyzed. Manifestations of collapse and sclerotic changes in the glomeruli, observations of collapse in the Bowman's space, ex¬ cessive accumulation in the ultrafiltrate and dilata¬ tion was noted in the I/R group. The average diame¬ ter of the glomeruli and the scores of injury were sig¬ nificantly different between the I/R and FGF20 groups and the I/R and Ozone 50 groups (p<0.05). The histopathologic assessment showed that the treatment with FGF-2 or ozone had renoprotective effects against renal damage caused by I/R in a dose-dependent manner. This study may discover a new therapeutic strategy for the treatment of AKI based on specified pathogenesis. This study found the FGF-2 and ozone applications to be beneficial for the treatment of AKI at the cellular level with certain doses. © 2020 Parlar Scientific Publications. All rights reserved.en_US
dc.identifier.endpage11150en_US
dc.identifier.issn1018-4619
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85099361288en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage11143en_US
dc.identifier.urihttps://hdl.handle.net/11616/90885
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute kidney injuryen_US
dc.subjectFGF-2en_US
dc.subjectIschemia-reperfusionen_US
dc.subjectOzone applicationsen_US
dc.titleThe effects of fibroblast growth factor-2 and ozone therapy on acute kidney injury in renal ischemia/reperfusion injuryen_US
dc.typeArticleen_US

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