Aminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats

Basit Öğe Kaydı
dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTimurkaan, Necati/0000-0001-5567-991X
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidTimurkaan, Necati/V-7016-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorOguz, F.
dc.contributor.authorCiftci, O.
dc.contributor.authorAydin, M.
dc.contributor.authorTimurkaan, N.
dc.contributor.authorBeytur, A.
dc.contributor.authorAltintas, R.
dc.contributor.authorParlakpinar, H.
dc.date.accessioned2024-08-04T20:37:42Z
dc.date.available2024-08-04T20:37:42Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, it was aimed to determinate protective effects of aminoguanidine (AG) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. Thirty-two rats were equally divided into four groups; the first group was kept as control and given corn oil as carrier. In second and third groups, TCDD and AG were orally administered at the dose of 2 mu k g(-1) per week and 100 mg kg(-1) per day for 45 days, respectively. In fourth group, TCDD and AG were given together at the same doses. Although TCDD significantly increased the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx and SOD in rats. On the other hand, AG, given together TCDD, reversed TCDD effects on TBARS SOD, GSH, GPx and CAT. In addition, sperm characteristics negatively affected and histopathological deformation occurred with TCDD exposure. However, AG treatment partly prevented these toxic effects of TCDD on spermatological parameters and histopathological changes. In conclusion, TCDD exposure induces testicular damage (oxidative stress, histopathological damage and sperm parameters), and AG treatment reversed TCDD-induced testicular damage in rats. Thus, AG may be useful for the prevention and treatment of TCDD-induced male infertility problems.en_US
dc.identifier.doi10.1111/j.1439-0272.2012.01334.x
dc.identifier.endpage231en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue4en_US
dc.identifier.pmid22762285en_US
dc.identifier.scopus2-s2.0-84879876755en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage225en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0272.2012.01334.x
dc.identifier.urihttps://hdl.handle.net/11616/96124
dc.identifier.volume45en_US
dc.identifier.wosWOS:000322154200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAminoguanidineen_US
dc.subjectoxidative damageen_US
dc.subjectsperm qualityen_US
dc.subjecttesticular damageen_US
dc.subject2,3,7,8-tetrachlorodibenzo-p-dioxinen_US
dc.titleAminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu