Serum Inflammation Parameters and Survival in Hepatocellular Carcinoma Patients: Importance of Albumin and Gamma-Glutamyltranspeptidase

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dc.authoridCarr, Brian/0000-0002-6111-5077
dc.contributor.authorCarr, Brian I. I.
dc.contributor.authorGuerra, Vito
dc.date.accessioned2024-08-04T20:53:45Z
dc.date.available2024-08-04T20:53:45Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Many single and combination blood tests that reflect local or systemic inflammation have been shown to be useful prognosticators in patients with a variety of tumor types. To try to clarify, this issue in patients with nonsurgically treatable hepatocellular carcinoma, multiple serum parameters were evaluated for their relationship to survival. Methods: A prospectively collected database was interrogated of 487 patients with known hepatocellular carcinoma and documented survival and having all the inflammation parameters of interest in this study, together with baseline tumor characteristics from CT scans. Serum parameters included NLR, PLR, CRP, ESR, albumin, and GGT. Results: All the parameters had significant hazard ratios on Cox regression model. Combination double parameters with hazard ratios >2.0 were: ESR plus GGT, albumin plus GGT, albumin plus ESR. The triplet combination of albumin plus GGT plus ESR had a hazard ratio of 6.33. Using Harrell's concordance index (C-index), the highest inflammation-based 2-parameter prognostic score was for albumin plus GGT. When clinical characteristics of patients with high values for albumin plus low values for GGT were compared to low values for albumin plus high values for GGT (worse prognosis), statistically significant differences were found for tumor size, tumor focality, macroscopic portal vein invasion, and serum alpha-fetoprotein levels. Addition of ESR did not provide additional tumor information. Conclusion: The combination of serum albumin plus GGT levels was the most prognostically useful among the inflammation parameters that were tested, and reflected significant differences in tumor aggressiveness characteristics.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by NIH Grant CA 82723 (B.I.C).en_US
dc.identifier.doi10.1159/000527650
dc.identifier.endpage320en_US
dc.identifier.issn0030-2414
dc.identifier.issn1423-0232
dc.identifier.issue5en_US
dc.identifier.pmid36878197en_US
dc.identifier.scopus2-s2.0-85160969833en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.1159/000527650
dc.identifier.urihttps://hdl.handle.net/11616/101385
dc.identifier.volume101en_US
dc.identifier.wosWOS:000946838400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectSurvivalen_US
dc.subjectGGTen_US
dc.subjectAlbuminen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.titleSerum Inflammation Parameters and Survival in Hepatocellular Carcinoma Patients: Importance of Albumin and Gamma-Glutamyltranspeptidaseen_US
dc.typeArticleen_US

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