Is FDG-PET/CT used correctly in the combined approach for nodal staging in NSCLC patients?

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dc.authoridUlutas, Hakki/0000-0001-9603-7323
dc.authoridÇavuşoğlu Yalçın, Nilay/0000-0002-0675-9267
dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456
dc.authoridElmalı, Ferhan/0000-0002-1967-1811
dc.authorwosidUlutas, Hakki/AAS-3954-2020
dc.authorwosidÇavuşoğlu Yalçın, Nilay/F-9446-2019
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.authorwosidElmalı, Ferhan/E-2943-2015
dc.contributor.authorSimsek, F. S.
dc.contributor.authorComak, A.
dc.contributor.authorAsik, M.
dc.contributor.authorKuslu, D.
dc.contributor.authorBalci, T. A.
dc.contributor.authorUlutas, H.
dc.contributor.authorKoroglu, R.
dc.date.accessioned2024-08-04T20:47:24Z
dc.date.available2024-08-04T20:47:24Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The most widely accepted approach nowadays in nodal staging of non-small cell lung cancer (NSCLC) is the combined use of 18-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA). However, this approach may not be sufficient, especially for early stages. Aims: Our aim was to assess whether more satisfactory results can be obtained with standardized uptake value maximum lymph node/standardized uptake value mean mediastinal blood pool (SUVmax LN/SUVmean MBP), SUVmax LN/Primary tumor, or a novel cut-off value to SUVmax in this special group. Subjects and Methods: Patients with diagnosed NSCLC and underwent FDG-PET/CT were reviewed retrospectively. 168 LNs of 52 early stage NSCLC patients were evaluated. The LNs identified in surgery/pathology reports were found in the FDG-PET/CT images. Anatomic and metabolic parameters were measured. Statistical analysis was performed by using of MedCalc Statistical Software. Results: Regardless of LNs size; sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of SUVmax >2.5 were 91.5%, 65.9%, 58.2%, and 95.1%, respectively. Optimum cut-off value of SUVmax was >4.0. Sensitivity, specificity, PPV, and NPV were found as 81.0%, 90.0%, 81.0%, and 90.0% respectively. Optimum cut-off value of SUVmax LN/SUVmean MBP was >1.71. Sensitivity, specificity, PPV, and NPV were found as 94.7%, 80.0%, 71.1%, and 96.7%, respectively. Optimum cut-off value of SUVmax LN/Primary tumor was >0.28. Sensitivity, specificity, PPV, and NPV were found as 81.1%, 85.1%, 72.9% and 90.1%, respectively. Conclusion: SUVmax LN/SUVmean MBP >1.71 has higher PPV than currently used, with similar NPV and sensitivity. This can provide increase in the accuracy of combined approach. In this way, faster nodal staging/treatment decisions, cost savings for healthcare system and time saving of medical professionals can be obtained.en_US
dc.identifier.doi10.4103/njcp.njcp_2_19
dc.identifier.endpage847en_US
dc.identifier.issn1119-3077
dc.identifier.issue6en_US
dc.identifier.pmid32525121en_US
dc.identifier.scopus2-s2.0-85086355404en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage842en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_2_19
dc.identifier.urihttps://hdl.handle.net/11616/99347
dc.identifier.volume23en_US
dc.identifier.wosWOS:000543398100016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEBUS-TBNAen_US
dc.subjectFDG-PETen_US
dc.subjectCTen_US
dc.subjectNSCLCen_US
dc.subjectstagingen_US
dc.titleIs FDG-PET/CT used correctly in the combined approach for nodal staging in NSCLC patients?en_US
dc.typeArticleen_US

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