Colistin nephrotoxicity increases with age

Basit Öğe Kaydı
dc.authoriduzun, sami/0000-0002-7843-164X
dc.authoridbalkan, ilker inanc/0000-0002-8977-5931
dc.authoridKarabay, Oguz/0000-0003-1514-1685
dc.authoridOzkan, Ahmet Selim/0000-0002-4543-8853
dc.authoridDurdu, Bulent/0000-0002-0244-4006
dc.authoridHakyemez, Ismail/0000-0001-6133-9604
dc.authoridAkbas, Sedat/0000-0003-3055-9334
dc.authorwosiduzun, sami/GRX-9084-2022
dc.authorwosidbalkan, ilker inanc/AAI-1578-2019
dc.authorwosidTabak, Ömer Fehmi/A-1192-2018
dc.authorwosidKarabay, Oguz/HHN-5893-2022
dc.authorwosidOzkan, Ahmet Selim/ABH-2918-2020
dc.authorwosidDurdu, Bulent/I-7851-2016
dc.authorwosidHakyemez, Ismail/J-2404-2015
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorDogan, Mustafa
dc.contributor.authorDurdu, Bulent
dc.contributor.authorBatirel, Ayse
dc.contributor.authorHakyemez, Ismail N.
dc.contributor.authorCetin, Birsen
dc.contributor.authorKarabay, Oguz
dc.date.accessioned2024-08-04T20:39:51Z
dc.date.available2024-08-04T20:39:51Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Colistin (COL) has become the backbone of the treatment of infections due to extensively drug-resistant (XDR) Gram-negative bacteria. The most common restriction to its use is acute kidney injury (AKI). Methods: We conducted a retrospective cohort study to evaluate risk factors for new-onset AKI in patients receiving COL. The cohort consisted of 198 adults admitted to 9 referral hospitals between January 2010 and October 2012 and treated with intravenous COL for >= 72 h. Patients with no pre-existing kidney dysfunction were compared in terms of risk factors and outcomes of AKI graded according to the RIFLE criteria. Logistic regression analysis was used to identify associated risk factors. Results: A total of 198 patients met the inclusion criteria, of whom 167 had no pre-existing kidney dysfunction; the mean patient age was 58.77 (+/- 18.98) y. Bloodstream infections (34.8%) and ventilator-associated pneumonia (32.3%) were the 2 most common indications for COL use. New-onset AKI developed in 46.1% of the patients, graded as risk (10%), injury (15%), and failure (21%). Patients with high Charlson co-morbidity index (CCI) scores (p = 0.001) and comparatively low initial glomerular filtration rate (GFR) estimations (p < 0.001) were more likely to develop AKI, but older age (p = 0.001; odds ratio 5.199, 95% confidence interval 2.684-10.072) was the major predictor in the multivariate analysis. In-hospital recovery from AKI occurred in 58.1%, within a median of 7 days. Conclusions: COL-induced nephrotoxicity occurred significantly more often in patients older than 60 y of age and was related to low initial GFR estimations and high CCI scores, which were basically determined by age.en_US
dc.identifier.doi10.3109/00365548.2014.926021
dc.identifier.endpage685en_US
dc.identifier.issn0036-5548
dc.identifier.issn1651-1980
dc.identifier.issue10en_US
dc.identifier.pmid25073536en_US
dc.identifier.scopus2-s2.0-84907147374en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage678en_US
dc.identifier.urihttps://doi.org/10.3109/00365548.2014.926021
dc.identifier.urihttps://hdl.handle.net/11616/96550
dc.identifier.volume46en_US
dc.identifier.wosWOS:000342202800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofScandinavian Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColistinen_US
dc.subjectnephrotoxicityen_US
dc.subjectageen_US
dc.titleColistin nephrotoxicity increases with ageen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu