Antioxidative and metabolic responses to extended cold exposure in rats

Basit Öğe Kaydı
dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authoridAsma, Dilek/0000-0002-3866-3016
dc.authoridYesilada, Ozfer/0000-0003-0038-6575
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.authorwosidAsma, Dilek/AAA-5294-2021
dc.authorwosidYesilada, Ozfer/ABI-1335-2020
dc.contributor.authorYuksel, Sengul
dc.contributor.authorAsma, Dilek
dc.contributor.authorYesilada, Ozfer
dc.date.accessioned2024-08-04T20:30:42Z
dc.date.available2024-08-04T20:30:42Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this work, we investigated whether extended cold exposure increases oxidative damage and susceptibility to oxidants of rat liver, heart, kidney and lung which are metabolically active tissues. Moreover in this study the effect of cold stress on some of the lipid metabolic mediators were studied in rat experimental model. Male albino Sprague-Dawley rats were randomly divided into two groups: The control group (n = 12) and the cold-stress group (n = 12). Tissue superoxide dismutase (SOD), catalase (CAT), glutathion S-transferase (GST) and glutathion reductase (GR) activities and glutathion (GSH) were measured using standard protocols. The biochemical analyses for total lipid, cholesterol, trigliceride, HDL, VLDL and LDL were done on autoanalyzer. In cold-stress groups SOD activity was decreased in the lung whereas it increased in the heart and kidney. CAT activity was significantly decreased (except liver) in all the tissues in treated rats. GST activity of cold-induced rats increased in liver and heart while decreased in the lung. GR activity was significantly decreased (except in liver) in all the tissues in cold-stressed rats. GSH level was significantly increased in the heart but decreased in the lung of animals exposed to cold when compared to controls. It was found that among the groups trigliceride, total lipid, HDL and VLDL parameters varied significantly but cholesterol and LDL had no significant variance. In this study, we found that exposure of extended (48 h) cold (8 C) caused changes both in the antioxidant defense system (as tissue and enzyme specific) and serum lipoprotein profiles in rats.en_US
dc.identifier.doi10.1556/ABiol.59.2008.1.5
dc.identifier.endpage66en_US
dc.identifier.issn0236-5383
dc.identifier.issn1588-256X
dc.identifier.issue1en_US
dc.identifier.pmid18401945en_US
dc.identifier.scopus2-s2.0-40049092251en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1556/ABiol.59.2008.1.5
dc.identifier.urihttps://hdl.handle.net/11616/94470
dc.identifier.volume59en_US
dc.identifier.wosWOS:000253256600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Biologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcold stressen_US
dc.subjectoxidative stressen_US
dc.subjectglutathioneen_US
dc.subjectantioxidant enzymesen_US
dc.subjectlipid metabolismen_US
dc.subjectraten_US
dc.titleAntioxidative and metabolic responses to extended cold exposure in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu