Propofol and erythropoietin antioxidant properties in rat brain injured tissue

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dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorOzturk, Erdogan
dc.contributor.authorDemirbilek, Semra
dc.contributor.authorKoroglu, Ahmet
dc.contributor.authorBut, Abdulkadir
dc.contributor.authorBegec, Zekine Oezpolat
dc.contributor.authorGulec, Mukaddes
dc.contributor.authorAkyol, Omer
dc.date.accessioned2024-08-04T20:30:39Z
dc.date.available2024-08-04T20:30:39Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSo far, several treatment modalities have been attempted to brain protection in cases such as brain trauma, stroke or brain hemorrhage. However, a treatment method that the effect begins immediately and definitely helpful has not been discovered yet. In this study, we aimed to compare the effects of propofol and erythropoietin (Epo) on brain injury caused by oxidative stress and antioxidant properties of these agents after closed head injury (CHI) in rats. For this study, female Wistar Albino rats were divided into five groups: non-traumatic control group, trauma performed group CHI, trauma with propofol (100 mg/kg) intraperitoneally (i.p.), trauma with Epo (5000 U/kg) i.p. and trauma with propofol and Epo performed study groups. Twenty-four hours after CHI, rats were sacrificed and the brains were removed. Superoxide dismutase (SOD), catalase (CAT), xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA) levels were measured in brain tissue. MDA and NO levels were decreased significantly in Groups Epo, Propofol and Epo + Propofol than Group CHI (p < 0.0 1). XO activity was significantly lower in Group Epo than Group CHI (p <0.05). Epo and propofol decreased oxidative stress by decreasing MDA and NO level in brain tissue after CHI. However, combination of Epo and propofol has no significant beneficial advantage than Epo or propofol alone. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2007.07.016
dc.identifier.endpage86en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue1en_US
dc.identifier.pmid17764798en_US
dc.identifier.scopus2-s2.0-38349025897en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2007.07.016
dc.identifier.urihttps://hdl.handle.net/11616/94430
dc.identifier.volume32en_US
dc.identifier.wosWOS:000253565500011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectclosed head injuryen_US
dc.subjecterythropoietinen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectpropofolen_US
dc.titlePropofol and erythropoietin antioxidant properties in rat brain injured tissueen_US
dc.typeReview Articleen_US

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