Artificial Intelligence-based Colon Cancer Prediction by Identifying Genomic Biomarkers

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dc.contributor.authorPaksoy, Nur
dc.contributor.authorYağın, Fatma Hilal
dc.date.accessioned2024-08-04T19:53:15Z
dc.date.available2024-08-04T19:53:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Colon cancer is the third most common type of cancer worldwide. Because of the poor prognosis and unclear preoperative staging, genetic biomarkers have become more important in the diagnosis and treatment of the disease. In this study, we aimed to determine the biomarker candidate genes for colon cancer and to develop a model that can predict colon cancer based on these genes.Material and Methods: In the study, a dataset containing the expression levels of 2000 genes from 62 different samples (22 healthy and 40 tumor tissues) obtained by the Princeton University Gene Expression Project and shared in the figshare database was used. Data were summarized as mean ± standard deviation. Independent Samples T-Test was used for statistical analysis. The SMOTE method was applied before the feature selection to eliminate the class imbalance problem in the dataset. The 13 most important genes that may be associated with colon cancer were selected with the LASSO feature selection method. Random Forest (RF), Decision Tree (DT), and Gaussian Naive Bayes methods were used in the modeling phase.Results: All 13 genes selected by LASSO had a statistically significant difference between normal and tumor samples. In the model created with RF, all the accuracy, specificity, f1-score, sensitivity, negative and positive predictive values were calculated as 1. The RF method offered the highest performance when compared to DT and Gaussian Naive Bayes.Conclusion: In the study, we identified the genomic biomarkers of colon cancer and classified the disease with a high-performance model. According to our results, it can be recommended to use the LASSO+RF approach when modeling high-dimensional microarray data. en_US
dc.identifier.doi10.37990/medr.1077024
dc.identifier.endpage202en_US
dc.identifier.issn2687-4555
dc.identifier.issue2en_US
dc.identifier.startpage196en_US
dc.identifier.trdizinid1124951en_US
dc.identifier.urihttps://doi.org/10.37990/medr.1077024
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124951
dc.identifier.urihttps://hdl.handle.net/11616/89603
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedical records-international medical journal (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleArtificial Intelligence-based Colon Cancer Prediction by Identifying Genomic Biomarkersen_US
dc.typeArticleen_US

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