Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridyilmaz, zehra/0000-0002-9523-7718
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidyılmaz, zehra/ABF-5526-2020
dc.contributor.authorFadillioglu, Ersin
dc.contributor.authorKurcer, Zehra
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorIraz, Mustafa
dc.contributor.authorGursul, Cebrail
dc.date.accessioned2024-08-04T20:30:51Z
dc.date.available2024-08-04T20:30:51Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description31st National Congress of the Turkish-Physiological-Society -- SEP 27-30, 2005 -- Gaziantep, TURKEYen_US
dc.description.abstractOxidative stress may have a role in liver damage after acute renal injury due to various reasons such as ischemia reperfusion (IR). Diabetes mellitus (DM) is an important disease for kidneys and may cause nephropathy as a long term complication. The aim of this study was to investigate protective effect of melatonin, a potent antioxidant, against distant organ injury on liver induced by renal IR in rats with or without DM. The rats were divided into six groups: control (n=7), DM (n=5), IR (n=7), DM+IR (n=7), melatonin+IR (Mel+IR) (melatonin, 4 mg/kg during 15 days) (n=7), and Mel+DM+IR groups (n=7). Diabetes developed 3 days after single i.p. dose of 45 mg/kg streptozotocin. After 15 day, the left renal artery was occluded for 30 min followed 24 h of reperfusion in IR performed groups. DM did not alter oxidative parameters alone in liver tissue. The levels of malondialdehyde, protein carbonyl and nitric oxide with activities of xanthine oxidase and myeloperoxidase were increased in liver tissues of diabetic and non-diabetic IR groups. Nitric oxide level in DM was higher than control. The activities of catalase and superoxide dismutase were increased in IR groups in comparison with control and DM. ALT and AST levels were higher in IR and DM+IR groups than control and DM. Melatonin treatment reversed all these oxidant and antioxidant parameters to control values as well as serum liver enzymes. We concluded that renal IR may affect distant organs such as liver and oxidative stress may play role on this injury, but DM has not an effect on kidney induced distant organ injury via oxidant stress. Also, it was concluded that melatonin treatment may prevent liver oxidant stress induced by distant injury of kidney IR.en_US
dc.description.sponsorshipTurkish Phys Socen_US
dc.identifier.doi10.1007/s12272-001-1216-3
dc.identifier.endpage712en_US
dc.identifier.issn0253-6269
dc.identifier.issn1976-3786
dc.identifier.issue6en_US
dc.identifier.pmid18563351en_US
dc.identifier.scopus2-s2.0-45749113029en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage705en_US
dc.identifier.urihttps://doi.org/10.1007/s12272-001-1216-3
dc.identifier.urihttps://hdl.handle.net/11616/94575
dc.identifier.volume31en_US
dc.identifier.wosWOS:000256838800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Koreaen_US
dc.relation.ispartofArchives of Pharmacal Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdistant organ injuryen_US
dc.subjectliveren_US
dc.subjectrenal ischemia reperfusionen_US
dc.subjectmelatoninen_US
dc.subjectdiabetesen_US
dc.subjectoxidative stressen_US
dc.titleMelatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitusen_US
dc.typeConference Objecten_US

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