High-resolution 1H-NMR spectroscopy indicates variations in metabolomics profile of follicular fluid from women with advanced maternal age

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dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridDogan, Berat/0000-0003-4810-1970
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidmumcu, akın/ABG-9283-2020
dc.authorwosidTuncay, Görkem/ABI-6418-2020
dc.authorwosidDogan, Berat/AAJ-7288-2020
dc.contributor.authorDogan, B.
dc.contributor.authorKaraer, A.
dc.contributor.authorTuncay, G.
dc.contributor.authorTecellioglu, N.
dc.contributor.authorMumcu, A.
dc.date.accessioned2024-08-04T20:47:05Z
dc.date.available2024-08-04T20:47:05Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim To reveal whether there are differences in follicular fluid metabolomics profile of women with advanced maternal age (AMA). Method The group with advanced maternal age includes 23 patients above the age of 40, and the control group includes 31 patients aged between 25 and 35 years and AMH values above 1.1 ng/mL with no low ovarian response history. A single follicular fluid sample from a MII oocyte obtained during the oocyte pick-up procedure was analyzed with high-resolution H-1-NMR (nuclear magnetic resonance) spectroscopy. The results were evaluated using advanced bioinformatics analysis methods. Results Statistical analysis of the NMR spectroscopy data from two groups showed that alpha-glucose and beta-glucose levels of follicular fluid were decreased in the patients with AMA, while in contrast, lactate and trimethylamine N-oxide (TMAO) levels were increased in these patients compared with the controls. In addition to these, there was an increase in alanine levels and a decrease in acetoacetate levels in patients with AMA. However, these changes were not statistically significant. Conclusion Obtained results suggest that the follicular cell metabolism of patients with AMA is different from controls. These environmental changes could be associated with the low success rates of IVF treatment seen in these patients.en_US
dc.description.sponsorshipscientific research projects unit of Inonu University [2016/56]en_US
dc.description.sponsorshipThis study was supported by the scientific research projects unit of Inonu University (Grant Number 2016/56).en_US
dc.identifier.doi10.1007/s10815-020-01693-x
dc.identifier.endpage330en_US
dc.identifier.issn1058-0468
dc.identifier.issn1573-7330
dc.identifier.issue2en_US
dc.identifier.pmid31942667en_US
dc.identifier.scopus2-s2.0-85078629503en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-020-01693-x
dc.identifier.urihttps://hdl.handle.net/11616/99162
dc.identifier.volume37en_US
dc.identifier.wosWOS:000507352600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolomicsen_US
dc.subjectNMRen_US
dc.subjectAdvanced maternal ageen_US
dc.subjectFollicular fluiden_US
dc.titleHigh-resolution 1H-NMR spectroscopy indicates variations in metabolomics profile of follicular fluid from women with advanced maternal ageen_US
dc.typeArticleen_US

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