Beneficial effects of ?-glucan against cisplatin side effects on the nervous system in rats

Basit Öğe Kaydı
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridTecellioglu, Mehmet/0000-0002-8381-9630
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidTecellioglu, Mehmet/AAA-3220-2021
dc.contributor.authorKaya, Kursat
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorTecellioglu, Mehmet
dc.contributor.authorBasak, Nese
dc.date.accessioned2024-08-04T20:41:38Z
dc.date.available2024-08-04T20:41:38Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, beta g was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and beta g were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, beta g treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and ag supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that Ag might be useful against CP toxicity in patients with cancer in terms of nervous system.en_US
dc.identifier.doi10.1590/S0102-865020160030000008
dc.identifier.endpage205en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue3en_US
dc.identifier.pmid27050791en_US
dc.identifier.scopus2-s2.0-84962362128en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160030000008
dc.identifier.urihttps://hdl.handle.net/11616/97249
dc.identifier.volume31en_US
dc.identifier.wosWOS:000374189100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectbeta-Glucansen_US
dc.subjectNervous Systemen_US
dc.subjectOxidative Stressen_US
dc.subjectRatsen_US
dc.titleBeneficial effects of ?-glucan against cisplatin side effects on the nervous system in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu