Protocatechuic acid prevents reproductive damage caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats

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dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridYILMAZ, Fethi/0000-0002-5041-9390
dc.authoridTimurkaan, Necati/0000-0001-5567-991X
dc.authoridCakir, Oguz/0000-0002-8006-2054
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTimurkaan, Necati/V-7016-2018
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidYILMAZ, Fethi/W-9442-2018
dc.authorwosidÇakır, Oğuz/CAF-8360-2022
dc.contributor.authorBeytur, A.
dc.contributor.authorCiftci, O.
dc.contributor.authorAydin, M.
dc.contributor.authorCakir, O.
dc.contributor.authorTimurkaan, N.
dc.contributor.authorYilmaz, F.
dc.date.accessioned2024-08-04T20:35:54Z
dc.date.available2024-08-04T20:35:54Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, it was aimed to determinate beneficial effects of protocatechuic acid (PCA) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. For this purpose, 28 rats were equally divided into four groups (control, TCDD 2 mu g kg-1 per week, PCA 100 mg kg-1 per day and TCDD + PCA group), and compounds were orally administered for 45 days. The results indicated that TCDD induced oxidative stress via an increase in thiobarbituric acid-reactive substances levels and a decrease in reduced glutathione, catalase, glutathione peroxidise and SOD levels in male rats. In contrast, PCA treatment prevented toxic effects of TCDD in terms of oxidative stress. Additionally, sperm motility, sperm concentration and serum testosterone levels significantly decreased, and pathologic testicular damage increased with TCDD exposure. However, these effects of TCDD on sperm characteristics, histopathological changes and hormone levels were reversed by PCA treatment. In conclusion, it was found that TCDD exposure induced reproductive toxicity (oxidative, hormonal, histopathological and spermatological alternations) in male rats and PCA treatment could prevent toxic effects of TCDD. Thus, PCA may be useful for the prevention and treatment of reproductive toxicity caused by TCDD.en_US
dc.identifier.doi10.1111/j.1439-0272.2011.01204.x
dc.identifier.endpage461en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.pmid21806661en_US
dc.identifier.scopus2-s2.0-84861519953en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage454en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0272.2011.01204.x
dc.identifier.urihttps://hdl.handle.net/11616/95670
dc.identifier.volume44en_US
dc.identifier.wosWOS:000304439300062en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2en_US
dc.subject3en_US
dc.subject7en_US
dc.subject8-TCDDen_US
dc.subjectprotocatechuic aciden_US
dc.subjectreproductive toxicityen_US
dc.subjecttesticular damageen_US
dc.subjecttestosteroneen_US
dc.titleProtocatechuic acid prevents reproductive damage caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male ratsen_US
dc.typeArticleen_US

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