Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-?, and IFN-? levels in drug-free, comorbidity-free obsessive-compulsive disorder patients

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dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoriderbay, lale gönenir/0000-0002-9969-3016
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.authorwosiderbay, lale gönenir/AAE-6285-2019
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorErbay, Lale Gonenir
dc.contributor.authorAkti Kavuran, Nursel
dc.contributor.authorTaskapan, Cagatay
dc.contributor.authorInce, Lara Utku
dc.contributor.authorYologlu, Saim
dc.contributor.authorTemelli, Husniye Gul
dc.contributor.authorUnal, Suheyla
dc.date.accessioned2024-08-04T20:44:07Z
dc.date.available2024-08-04T20:44:07Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Increasing evidence suggests that certain inflammatory factors, especially cytokines, can lead to neurochemical and behavioural changes via their role in the brain signalling system. Studies investigating cytokine abnormalities in obsessive-compulsive disorder (OCD) have yielded conflicting results thus far. The aim of this study was to investigate the serum IL-1, IL-4, IL-6, IL-10, TNF-alpha, and IFN-gamma levels in drug-free, comorbidity-free patients with OCD. Methods: Forty comorbidity-free, drug-free OCD patients and 40 age-and sex-matched healthy volunteers were included in the study. Clinical severity was assessed using the Yale-Brown Obsessive-Compulsive Evaluation Scale (YBOCES). Results: IL-1 levels were significantly higher and IL-2, IL-6, and TNF-alpha levels were significantly lower in patients than in controls. No differences were observed in IL-4, IL-10, and IFN-gamma levels. However, a negative relationship was found between IL-1 levels and compulsive symptoms (YBOCES) in OCD patients. Conclusions: Our findings suggest the possible role of cytokines in the pathogenesis of OCD. It is important to continue investigating the role of cytokines and other immunological markers in both the etiology and treatment of OCD.en_US
dc.identifier.doi10.5455/apd.274680
dc.identifier.endpage162en_US
dc.identifier.issn1302-6631
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85034857162en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.5455/apd.274680
dc.identifier.urihttps://hdl.handle.net/11616/98039
dc.identifier.volume19en_US
dc.identifier.wosWOS:000428761900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOCDen_US
dc.subjectcytokinesen_US
dc.subjectimmunological markersen_US
dc.titleSerum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-?, and IFN-? levels in drug-free, comorbidity-free obsessive-compulsive disorder patientsen_US
dc.typeArticleen_US

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