Efficacy of regorafenib in the second-and third-line setting for patients with advanced hepatocellular carcinoma: A real life data of multicenter study from Turkey

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dc.authoridkose, fatih/0000-0002-0156-5973
dc.authoridgülmez, ahmet/0000-0002-3353-344X
dc.authoridErgun, Yakup/0000-0003-4784-6743
dc.authoridŞahin, Ahmet Bilgehan/0000-0002-7846-0870
dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authoridTurker, Sema/0000-0001-9040-7266
dc.authoridKilickap, Saadettin/0000-0003-1637-7390
dc.authorwosidkose, fatih/G-4827-2016
dc.authorwosidCaner, Burcu/AAE-8549-2022
dc.authorwosidgülmez, ahmet/ABI-8218-2020
dc.authorwosidErgun, Yakup/N-3273-2018
dc.authorwosidŞahin, Ahmet Bilgehan/AAM-4927-2020
dc.authorwosidHacioglu, Bekir/GZH-1824-2022
dc.authorwosidTurker, Sema/ABE-5926-2021
dc.contributor.authorHacioglu, Muhammet Bekir
dc.contributor.authorKostek, Osman
dc.contributor.authorKarabulut, Senem
dc.contributor.authorTastekin, Didem
dc.contributor.authorGoksu, Sema Sezgin
dc.contributor.authorAlandag, Celal
dc.contributor.authorAkagunduz, Baran
dc.date.accessioned2024-08-04T20:48:54Z
dc.date.available2024-08-04T20:48:54Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: After failure of the first-line sorafenib treatment in advanced or metastatic stage hepatocellular carcinoma (HCC), regorafenib is one of the newly-approved targeted agents. We aimed to evaluate the efficacy of regorafenib in patients with advanced HCC treated in the secondor third-line setting. Methods: In this retrospective and multicenter study, advanced HCC patients not eligible for local therapies, who received a secondor third-line regorafenib therapy after progression on the first-line sorafenib or sequential therapy with chemotherapy (CT) followed by sorafenib, were included. Results: In the first-line setting, 28 (28.9%) patients received CT and 69 (71.1%) patients received sorafenib. There were 24 (24.7%) patients who were intolerant to sorafenib. Disease control rate (DCR) was 53.6% for all patients treated with regorafenib, 62.3% in patients who received regorafenib in the second-line, and 32.1% for those receiving regorafenib in the third-line (p=0.007). Median progression-free survival (PFS) and overall survival (OS) were 5.6 (range; 4.3-6.9) and 8.8 (range, 6.3-11.3) months for all patients treated with regorafenib vs. 7.1 months and 10.3 months for patients who received regorafenib in the second-line vs. 5.1 and 8.7 months for patients who received regorafenib in the third-line, respectively; however, there was no statistically significant difference (p(PFS)=0.22 and p(OS)=0.85). Conclusion: Although receiving CT as a first-line therapy in advanced HCC patients did not affect the survival rates of subsequent regorafenib therapy, it might diminish the DCR of regorafenib.en_US
dc.identifier.endpage1903en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4en_US
dc.identifier.pmid33099930en_US
dc.identifier.scopus2-s2.0-85090483650en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1897en_US
dc.identifier.urihttps://hdl.handle.net/11616/99527
dc.identifier.volume25en_US
dc.identifier.wosWOS:000573102800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectregorafeniben_US
dc.subjectdisease control rateen_US
dc.subjectoverall survivalen_US
dc.subjectchemotherapyen_US
dc.subjectanti-VEGF therapyen_US
dc.titleEfficacy of regorafenib in the second-and third-line setting for patients with advanced hepatocellular carcinoma: A real life data of multicenter study from Turkeyen_US
dc.typeArticleen_US

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