Amikacin-induced acute renal injury in rats: protective role of melatonin

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorParlakpinar, H
dc.contributor.authorOzer, MK
dc.contributor.authorSahna, E
dc.contributor.authorVardi, N
dc.contributor.authorCigremis, Y
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:13:26Z
dc.date.available2024-08-04T20:13:26Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study is to test whether melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant and free radical scavenger, reduces the nephrotoxicity caused by amikacin (AK). Herein, we investigated the physiologic and pharmacological role of melatonin in influencing AK-induced nephrotoxicity. For this, pinealectomized (Px) and sham operated (non-Px) rats were used. Both AK and melatonin were administered to all groups. We investigated the effects of melatonin on AK-induced changes in levels of malondialdehyde (MDA), a lipid peroxidation product, glutathione (GSH), an antioxidant whose levels are influenced by oxidative stress, and blood urea nitrogen (BUN) and serum creatine (Cr) levels. Morphologic changes in the kidney were also examined by using light microscopy. MDA levels were found to be higher in Px than in non-Px AK-treated animals. Melatonin administration to Px rats reduced MDA levels. In relative to non-Px rats, Px animals treated with AK had significantly lower GSH concentrations while melatonin administration elevated GSH levels in the kidney; however, this stimulatory effect of melatonin was not observed in non-Px AK-treated rats. Treatment with AK alone resulted in significantly higher plasma Cr and BUN levels. Repeated administration of melatonin prevented the AK-induced elevation of plasma Cr and BUN levels. Morphologic damage to renal tubules as a result of AK was more severe in the renal cortex than in the medulla. The damage to the kidney induced by AK was reversed by melatonin in the Px rats. In conclusion, these results show that physiologic melatonin concentrations are important in reducing AK-induced renal damage, while pharmacologic concentrations of melatonin did not add to the beneficial effect.en_US
dc.identifier.doi10.1034/j.1600-079X.2003.00059.x
dc.identifier.endpage90en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue2en_US
dc.identifier.pmid12887650en_US
dc.identifier.scopus2-s2.0-0042591084en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-079X.2003.00059.x
dc.identifier.urihttps://hdl.handle.net/11616/93599
dc.identifier.volume35en_US
dc.identifier.wosWOS:000184345800004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamikacinen_US
dc.subjectmalondialdehydeen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectraten_US
dc.subjectrenal injuryen_US
dc.titleAmikacin-induced acute renal injury in rats: protective role of melatoninen_US
dc.typeArticleen_US

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