SYNTHESIS OF NEW 6-[4-(2-FLUOROPHENYLPIPERAZINE-1-YL)]-3(2H)-PYRIDAZINONE-2-ACETHYL-2-(SUBSTITUTEDBENZAL)HYDRAZONE DERIVATIVES AND EVULATION OF THEIR CYTOTOXIC EFFECTS IN LIVER AND COLON CANCER CELL LINES

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridOzdemir, Zenyep/0000-0003-4559-2305
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidOzdemir, Zenyep/AAJ-6384-2020
dc.contributor.authorOzdemir, Zeynep
dc.contributor.authorBasak-Turkmen, Nese
dc.contributor.authorAyhan, Idris
dc.contributor.authorCiftci, Osman
dc.contributor.authorUysal, Mehtap
dc.date.accessioned2024-08-04T20:45:43Z
dc.date.available2024-08-04T20:45:43Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, seven new 3(2H)-pyridazinone derivatives expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Their structures were confirmed by the IR, H-1-NMR, C-13-NMR spectra and elementary analyses. Compunds V-1-V-7 were tested on HEP3B (liver cancer) and HTC116 (colon cancer) cell lines for cytotoxicity by using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] proliferation assay. Human fibroblast cells were used as safety control in these tests. 6-[4-(2-Fluorophenyl)piperazine-1-yl]-3(2H)-pyridazinone-2-acetyl-2-(2-chlorobenzal) hydrazone (compound V-3) was the most active agent with respect to HEP3B and HTC116 cell lines.en_US
dc.identifier.doi10.1007/s11094-019-01927-y
dc.identifier.endpage929en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85061507978en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage923en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-019-01927-y
dc.identifier.urihttps://hdl.handle.net/11616/98655
dc.identifier.volume52en_US
dc.identifier.wosWOS:000461018000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpyridazinoneen_US
dc.subjectcytotoxicityen_US
dc.subjectliver canceren_US
dc.subjectcolon canceren_US
dc.titleSYNTHESIS OF NEW 6-[4-(2-FLUOROPHENYLPIPERAZINE-1-YL)]-3(2H)-PYRIDAZINONE-2-ACETHYL-2-(SUBSTITUTEDBENZAL)HYDRAZONE DERIVATIVES AND EVULATION OF THEIR CYTOTOXIC EFFECTS IN LIVER AND COLON CANCER CELL LINESen_US
dc.typeArticleen_US

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