Effects of NG-nitro L-arginine and corticosteroids on aqueous humor levels of nitric oxide and cytokines after cataract surgery

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorEr, H
dc.contributor.authorGündüz, A
dc.contributor.authorTurkoz, Y
dc.contributor.authorÇigli, A
dc.contributor.authorIsci, N
dc.date.accessioned2024-08-04T20:40:00Z
dc.date.available2024-08-04T20:40:00Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To assess the efficacy of nitric oxide synthesis (NOS) inhibitor, topical steroids, and nonsteroidal anti-inflammatory drugs on aqueous levels of nitric oxide (NO) and cytokines after cataract surgery. Setting: Research Laboratory, Inonu University Turgut Ozal Medical Center, Malatya, Turkey. Methods: Fifteen rabbits had intercapsular phacoemulsification and were randomly divided into 3 treatment groups: Group 1 was treated with topical prednisolone acetate 1% drops 5 times a day for 1 week; Group 2, flurbiprofen 0.03% drops 5 times a day for 1 week; Group 3, a 0.1 cc subconjunctival injection of NG-nitro L-arginine (L-NAME) (150 mg/kg) 1 day and 3 days after surgery. Three rabbits serving as controls received a subconjunctival injection of an equal volume of balanced salt solution (BSS(R)) at the same times as the L-NAME injections. Aqueous humor specimens were collected from each eye to determine NO and cytokine levels including interleukin-1-beta (IL-1 beta), interleukin-2R (IL-2R), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), Results: The levels of IL-1 beta and IL-6 were higher in Group 2 and the control group than in Groups 1 and 3 at ail times. The differences were not statistically significant (P <.05), Nitric oxide and TNF-alpha levels in Groups 1 and 3 were significantly lower than in Groups 2 and the controls 1, 3, and 7 days postoperatively (P <.05). Conclusion: These findings suggest a strong inhibitory effect of NOS inhibitors and corticosteroids on aqueous levels of TNF-alpha and NO and no inhibitory effect on IL-1 beta and IL-6 levels after cataract surgery. J Cataract Refract Surg 1999; 25:794-799 (C) 1999 ASCRS and ESCRS.en_US
dc.identifier.doi10.1016/S0886-3350(99)00048-6
dc.identifier.endpage799en_US
dc.identifier.issn0886-3350
dc.identifier.issn1873-4502
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84920338632en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage794en_US
dc.identifier.urihttps://doi.org/10.1016/S0886-3350(99)00048-6
dc.identifier.urihttps://hdl.handle.net/11616/96648
dc.identifier.volume25en_US
dc.identifier.wosWOS:000080821200017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Cataract and Refractive Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndotoxin-Induced Uveitisen_US
dc.subjectInflammatory Mediatorsen_US
dc.subjectOcular Inflammationen_US
dc.subjectEndothelial-Cellsen_US
dc.subjectSynthaseen_US
dc.subjectInterleukin-1en_US
dc.subjectReceptoren_US
dc.titleEffects of NG-nitro L-arginine and corticosteroids on aqueous humor levels of nitric oxide and cytokines after cataract surgeryen_US
dc.typeArticleen_US

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