The Effects of Different Burn Dressings on Length of Telomere and Expression of Telomerase in Children With Thermal Burns

Basit Öğe Kaydı
dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridTaşçı, Aytaç/0000-0002-4024-5219
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridKOÇ, AHMET/0000-0003-3484-2137
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidTaşçı, Aytaç/AAA-2857-2021
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidKOÇ, AHMET/ABI-3322-2020
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorDemircan, Mehmet
dc.contributor.authorKoc, Ahmet
dc.contributor.authorKocbiyik, Alper
dc.contributor.authorTasci, Aytac
dc.contributor.authorDurmus, Kubra
dc.contributor.authorGurunluoglu, Semra
dc.date.accessioned2024-08-04T20:45:59Z
dc.date.available2024-08-04T20:45:59Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Burns are a common traumatic injury triggered by local tissue damage and a systemic response. In this study, we evaluated the effects of different burn dressings on telomere kinetics in children with thermal burn injury. Methods: Sixty children with thermal burn were included in this prospective study. The burn area of the patients included 20 to 50% total body surface area. Three different dressings (hydrofiber with silver [HFAg], poylactic membrane [PLM], and silver sulfadiazine [SSD]) and control groups were created. Telomere length in nucleated blood cells and telomerase expression in the skin tissue were evaluated in control and burn groups. Results: In the whole burn groups, telomere length in blood cells increased. The length of telomeres increased the most in the SSD group. The PLM group is the treatment that increases the number of squamous cell counts in the basal layer and telomerase expression in the skin. In HFAg and SSD groups, the expression of telomerase in the skin is decreased. In the HFAg group, the basal layer in the skin was also reduced in squamous cells. Conclusion: In all burn groups, the telomere length of nucleated cells in the blood was higher than in the control group. SSD dressing along with autografting is the treatment method that maximizes telomere length in blood cells. The PLM has the most increased telomerase expression in the skin of burned patients. The PLM application increases the number of cells on both burned and normal skin.en_US
dc.identifier.doi10.1093/jbcr/irz019
dc.identifier.endpage311en_US
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.issue3en_US
dc.identifier.pmid30805617en_US
dc.identifier.scopus2-s2.0-85066798912en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.1093/jbcr/irz019
dc.identifier.urihttps://hdl.handle.net/11616/98816
dc.identifier.volume40en_US
dc.identifier.wosWOS:000490449100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Burn Care & Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPartial-Thickness Burnsen_US
dc.subjectOxidative Stressen_US
dc.subjectReverse-Transcriptaseen_US
dc.subjectImage Jen_US
dc.subjectCellen_US
dc.subjectSilveren_US
dc.subjectApoptosisen_US
dc.subjectLactateen_US
dc.subjectGeneen_US
dc.subjectAssociationen_US
dc.titleThe Effects of Different Burn Dressings on Length of Telomere and Expression of Telomerase in Children With Thermal Burnsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu