Effects of apocynin on sciatic nerve injury in rabbits

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dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridtetik, bora/0000-0001-7696-7785
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoriddurak, mehmet akif akif/0000-0003-0827-2708
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidtetik, bora/AAA-8841-2021
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosiddurak, mehmet akif akif/ABI-1169-2020
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorDurak, Mehmet Akif
dc.contributor.authorOzhan, Onural
dc.contributor.authorTetik, Bora
dc.contributor.authorYildiz, Azibe
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorVardi, Nigar
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:53:12Z
dc.date.available2024-08-04T20:53:12Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effects of apocynin (APO) on experimental sciatic nerve compression injury in rabbits. We used 21 male rabbits divided randomly into three groups of seven. The control group was subjected to sciatic nerve compression with no further intervention. The APO treated group was subjected to compression injury and 20 mg/kg APO was administered daily for 21 days by intraperitoneal injection beginning the day after the injury. The sham group was treated with APO without injury. The control group exhibited shrinkage of axons, disruption of myelin sheaths and loss of nerve fibers. The damage for the control group was significantly greater than for the sham group. The severity of histopathology was decreased in the APO treated group compared to the control group, as was the oxidative stress index. Our findings suggest that APO treatment may contribute to healing of sciatic nerve damage.en_US
dc.identifier.doi10.1080/10520295.2022.2146195
dc.identifier.endpage178en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid36440649en_US
dc.identifier.scopus2-s2.0-85142882047en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage172en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2022.2146195
dc.identifier.urihttps://hdl.handle.net/11616/101024
dc.identifier.volume98en_US
dc.identifier.wosWOS:000891762800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApocyninen_US
dc.subjectcompression injuryen_US
dc.subjectrabbiten_US
dc.subjectsciatic nerveen_US
dc.titleEffects of apocynin on sciatic nerve injury in rabbitsen_US
dc.typeArticleen_US

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