Effects of agomelatine on rat liver regeneration following partial hepatectomy

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridKose, Adem/0000-0002-1853-1243
dc.authoridbilgic, yilmaz/0000-0002-2169-5548
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidSarıhan, Mehmet Ediz/JMQ-5971-2023
dc.authorwosidKose, Adem/AAD-1226-2020
dc.contributor.authorKose, A.
dc.contributor.authorOzhan, O.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorVardi, N.
dc.contributor.authorYildiz, A.
dc.contributor.authorTurkoz, Y.
dc.contributor.authorErdemli, Z.
dc.date.accessioned2024-08-04T20:53:11Z
dc.date.available2024-08-04T20:53:11Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrimary or metastatic hepatic malignancies are common. Partial hepatectomy (PH) is the primary treatment for both benign and malignant hepatic neoplasms; it also is used for living donor liver transplantation. The regenerative potential of the liver after PH is 70-80% in humans. We investigated the protective and therapeutic effects of agomelatine (AGM) on rat liver regeneration following PH. We used 32 rats distributed equally into four groups: group 1, sham control; group 2, PH group; group 3, administered 20 mg/kg AGM orally once/day for 7 days following PH; group 4, administered 20 mg/kg AGM orally once/day 3 days before and 7 days following PH for 10 days. Liver samples were analyzed for antioxidants and free radicals. Tissue samples were processed and stained with hematoxylin and eosin to assess histopathological status and stained immunohistochemically for Ki-67. We found that PH reduced antioxidant enzymes and increased tissue reactive oxygen species, whereas AGM treatment had the opposite effect on these parameters. Our biochemical and histopathological findings were consistent. PH caused sinusoid congestion and dilation. Intensity of Ki-67 immunostaining of hepatocytes was increased in group 2, whereas these were reduced in group 4. Intensity of Ki-67 immunostaining of hepatocytes was increased in group 2, whereas it was reduced in the group 4 compared to group 1. We found that AGM was hepatoprotective following PH due to its antioxidant and free radical scavenger properties.en_US
dc.identifier.doi10.1080/10520295.2022.2139862
dc.identifier.endpage165en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid36373333en_US
dc.identifier.scopus2-s2.0-85142140627en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2022.2139862
dc.identifier.urihttps://hdl.handle.net/11616/101000
dc.identifier.volume98en_US
dc.identifier.wosWOS:000883235800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAagomelatineen_US
dc.subjectantioxidanten_US
dc.subjecthepatectomyen_US
dc.subjectliveren_US
dc.subjectraten_US
dc.subjectregenerationen_US
dc.titleEffects of agomelatine on rat liver regeneration following partial hepatectomyen_US
dc.typeArticleen_US

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